Assessment of bone metabolism in cadmium-induced renal tubular dysfunction by measurements of biochemical markers
Assessment of bone metabolism in cadmium-induced renal tubular dysfunction by measurements of biochemical markers
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DOI：
10.1016/s0378-4274(02)00356-9
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发表时间：
2003-01-13
影响因子：
3.5
通讯作者：
Kasuya, M
中科院分区：
文献类型：
--
作者：
Aoshima, K;Fan, JJ;Kasuya, M
通过测量几种骨生化指标，评估与镉（Cd）诱导的肾小管功能障碍（RTD）严重程度相关的骨代谢。研究对象为日本富山津足川镉污染区53例女性RTD患者，年龄65-76岁（平均70.0 ± 3.3岁）。以血清骨碱性磷酸酶（bon-ALP）、完整骨钙素（intact-BGP）和I型胶原羧基端前肽（PICP）作为骨形成指标，以尿吡啶啉（Pyr）和脱氧吡啶啉（Dpyr）作为骨吸收指标。所有骨转换的标志物增加，并显着相互关联，表明骨形成和吸收耦合，并增加镉诱导的RTD。β 2-微球蛋白（β 2-m，FE β 2-m）的排泄分数作为Cd诱导RTD严重程度的指标变化很大，范围为0.45 - 53%。FEbeta 2-m与5种骨生化指标均无显著相关性。镉诱导的RTD中的骨转换似乎是由肾小球滤过率（GFR）决定的：在GFR高于50 ml/min的受试者中，骨ALP或完整BGP水平往往与GFR呈负相关，而在GFR低于40 ml/min的受试者中，这些水平往往下降。这些结果表明，骨转换，特别是骨形成，是受肾小管功能的影响，在镉诱导的RTD的GFR水平进行评估。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Bone metabolism related to the severity of cadmium (Cd)-induced renal tubular dysfunction (RTD) was assessed by measuring several bone biochemical markers. Fifty-three female subjects with RTD aged 65-76 years (mean 70.0+/-3.3 years) and who lived in the Cd-polluted Jinzu River basin in Toyama, Japan were studied. Bone alkaline phosphatase (bone-ALP), intact bone Gla-protein (intact-BGP) and carboxy-terminal propeptide of type I collagen (PICP) in serum as bone formation markers and pyridinoline (Pyr) and deoxypyridinoline (Dpyr) in urine as bone resorption markers were measured. All markers of bone turnover were increased and significantly correlated with each other, suggesting that bone formation and resorption were coupled and increased in Cd-induced RTD. Fractional excretion of beta(2)-microglobulin (beta(2)-m, FEbeta2-m) as an index of severity of Cd-induced RTD was extremely varied ranging from 0.45 to 53%. There were no significant correlations between FEbeta2-m and each of the five bone biochemical markers. The bone turnover in Cd-induced RTD appeared to be determined by the glomerular filtration rate (GFR): in subjects with GFRs above 50 ml/min, the levels of bone-ALP or intact-BGP tended to be inversely related to the GFRs, whereas in subjects with GFRs below 40 ml/min, those levels tended to decrease. These results suggest that the bone turnover, in particular the bone formation, was influenced by renal tubular function as assessed by the levels of GFR in Cd-induced RTD. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.