Swim bladder as an alternative biomaterial for bioprosthetic valves.
Swim bladder as an alternative biomaterial for bioprosthetic valves.
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DOI：
10.1039/d1bm01296g
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发表时间：
2021-11
影响因子：
6.6
通讯作者：
Ning Li;Xin Li;Ye Ma;F. Qiao;Yifan Bai;Xiaohong Liu;Zhiyun Xu
中科院分区：
文献类型：
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作者：
Ning Li;Xin Li;Ye Ma;F. Qiao;Yifan Bai;Xiaohong Liu;Zhiyun Xu
瓣膜结构退化和钙化是生物瓣膜置换术后二次干预的主要适应症，促进了对用于临床应用的更耐用的心血管生物材料的迫切需求。与牛心包相比，我们在本研究中引入的鲤鱼鱼鳔作为原始生物材料具有几个优点。首先，体外实验结果表明，与牛心包相比，交联鲤鱼鱼鳔具有上级生物相容性，并且通过大鼠皮下植入实验验证了其抗钙化性能。将交联后的鱼鳔组织缝合在钴铬合金支架上制成人工肺生物瓣膜，并通过体外疲劳试验验证其可行性和耐久性。最后，绵羊肺生物瓣膜置换原位实验进一步证实了鱼鳔上级的抗钙化性、免疫相容性、内皮化和血流动力学特性，表明其可能用作生物瓣膜的替代生物材料。
Valvular structural deterioration and calcification are the main indications for secondary intervention after bioprosthetic valve replacement, promoting an urgent requirement for more durable cardiovascular biomaterials for clinical applications. The swim bladder of carp we introduced in this study has several advantages as a raw biomaterial when compared to the bovine pericardium. First, the results of in vitro assays demonstrated that the cross-linked carp swim bladder exhibited superior biocompatibility compared to the bovine pericardium, and the anti-calcification property was verified by subcutaneous implantation experiments in rats. Furthermore, the cross-linked swim bladder tissue was sutured on a cobalt-chromium alloy stent to fabricate a pulmonary bioprosthetic valve, and then the feasibility and durability of the bioprosthetic valve were proved by a fatigue test in vitro. Finally, a sheep pulmonary bioprosthetic valve replacement in situ experiment further confirmed the superior calcification resistance, immune-compatibility, endothelialization, and hemodynamic properties of the swim bladder, suggesting that it might be used as an alternative biomaterial for bioprosthetic valves.