Emergence of antigenic variants within serotype A FMDV in the Middle East with antigenically critical amino acid substitutions.
Emergence of antigenic variants within serotype A FMDV in the Middle East with antigenically critical amino acid substitutions.
复制标题
DOI：
10.1016/j.vaccine.2016.02.057
复制
发表时间：
2016-06-08
期刊：
影响因子：
5.5
通讯作者：
Parida S
中科院分区：
文献类型：
--
作者：
Mahapatra M;Statham B;Li Y;Hammond J;Paton D;Parida S
最近在中东地区流行的A-Iran-05病毒与现有疫苗不匹配。产生了13种SIS-10和SIS-12病毒的完整衣壳序列。使用针对两种现有疫苗和一种新疫苗的抗血清产生的r1值。观察到中和抗原位点1、2和4的氨基酸变化。2003年在中东出现了一种新的免疫学上不同的A型口蹄疫病毒株（A-Iran-05），取代了以前在该地区流行的毒株（A-Iran-96和A-Iran-99）。这导致在2006年引入了该毒株的新疫苗（A/TUR/2006）。虽然这种疫苗株主要用于控制该地区的口蹄疫，但2012年和2013年分离的最近病毒显示出抗原漂移和与它的匹配性差。我们报告了目前流行的属于A-Iran-05的SIS-10和SIS-12亚系的病毒的抗原匹配结果和衣壳序列数据（2012年和2013年分离），突出了目前使用的血清型A疫苗的不足。这些结果在中东口蹄疫控制的背景下的影响进行了讨论。
The recent A-Iran-05 viruses circulating in the Middle East do not match with the existing vaccines. Full capsid sequence of 13 SIS-10 and SIS-12 viruses was generated. The r1-values generated using antisera raised against two existing vaccines and a new vaccine. Amino acid changes in neutralizing antigenic sites 1, 2 and 4 were observed. A new immunologically distinct strain (A-Iran-05) of foot-and-mouth disease virus serotype A emerged in the Middle East in 2003 that replaced the previously circulating strains (A-Iran-96 and A-Iran-99) in the region. This resulted in introduction of a new vaccine of this strain (A/TUR/2006) in 2006. Though this vaccine strain has been predominantly used to control FMD in the region, recent viruses isolated in 2012 and 2013 have shown antigenic drift and a poor match with it. In this study, we report the antigenic matching results and capsid sequence data of currently circulating viruses belonging to the SIS-10 and SIS-12 sub-lineages of A-Iran-05 (isolated in 2012 and 2013), highlighting the inadequacy of the currently used serotype A vaccines. Implications of these results in the context of FMD control in the Middle East are discussed.