The human endometrium as a sensor of embryo quality.
The human endometrium as a sensor of embryo quality.
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DOI：
10.1095/biolreprod.114.122846
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发表时间：
2014-10-01
影响因子：
3.6
通讯作者：
Brosens, Jan J
中科院分区：
文献类型：
--
作者：
Macklon, Nick S;Brosens, Jan J
人类生殖的特征是高度的胚胎浪费，这在很大程度上归因于胚胎非整倍体的高患病率。有人建议，产妇的战略已经发展，防止不适当的投资侵入性，但可行性差的胚胎。这一点的关键是子宫内膜作为生物传感器的新兴概念，首先在人类体外胚胎/蜕膜基质细胞共培养系统中发现，最近在体内小鼠模型中得到证实。在这篇综述中，越来越多的支持生物传感器组件的蜕膜化子宫内膜的实验证据概述，并描述了最近的见解胚胎衍生的信号检测子宫内膜和生物过程中，该信号被认为是转换成一个去或不去子宫内膜的反应的性质。最后，这个新的范例的临床意义的选择子宫的地址。
Human reproduction is characterized by a high degree of embryo wastage, which is largely ascribed to a high prevalence of embryo aneuploidy. It is proposed that maternal strategies have evolved that prevent inappropriate investment in invasive, but poorly viable embryos. Key to this is the emerging concept of the endometrium as biosensor, first identified in human in vitro embryo/decidualized stromal cell coculture systems and recently confirmed in an in vivo mouse model. In this review, the growing supporting experimental evidence for the biosensor component of decidualized endometrium is outlined, and recent insights into the nature of the embryo-derived signal detected by the endometrium and the biological processes by which this signal is thought to be converted into a go or no-go endometrial response are described. Finally, the clinical implications of this new paradigm of the choosy uterus are addressed.