Cutting edge:: TGF-β inhibits Th type 2 development through inhibition of GATA-3 expression
Cutting edge:: TGF-β inhibits Th type 2 development through inhibition of GATA-3 expression
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DOI：
10.4049/jimmunol.165.9.4773
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发表时间：
2000-11-01
影响因子：
4.4
通讯作者：
Flavell, RA
中科院分区：
文献类型：
--
作者：
Gorelik, L;Fields, PE;Flavell, RA
TGF-β是一种重要的免疫调节细胞因子，可以抑制效应T细胞的分化。在这份报告中，我们解决了TGF-β抑制CD 4（+）细胞分化为Th 2型细胞的分子机制。我们证明了TGF-β抑制发育中Th细胞的加塔-3表达。我们还表明，TGF-β抑制加塔-3表达是TGF-β抑制Th 2分化的主要机制，因为发育中的T细胞中加塔-3的异位表达克服了TGF-β抑制Th 2分化的能力。TGF-β可能在转录水平抑制加塔-3表达，并且这样做不干扰IL-4信号传导。
TGF-beta is an important immunomodulatory cytokine that can inhibit differentiation of effector T cells. In this report, we address the molecular mechanisms through which TGF-beta inhibits differentiation of CD4(+) cells into Th type 2 cells. We demonstrate that TGF-beta inhibits GATA-3 expression in developing Th cells. We also show that inhibition of GATA-3 expression by TGF-beta is a major mechanism of inhibition of Th2 differentiation by TGF-beta as ectopic expression of GATA-3 in developing T cells overcomes the ability of TGF-beta to inhibit Th2 differentiation. TGF-beta likely inhibits GATA-3 expression at the transcriptional level and does so without interfering with IL-4 signaling.