Transcriptional regulators of Na,K-ATPase subunits.
Transcriptional regulators of Na,K-ATPase subunits.
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DOI：
10.3389/fcell.2015.00066
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发表时间：
2015
影响因子：
5.5
通讯作者：
Langhans SA
中科院分区：
文献类型：
--
作者：
Li Z;Langhans SA
Na，K-ATP酶通常用作离子泵，产生跨质膜的电化学梯度，这对于跨上皮转运、营养吸收和膜电位是必不可少的。此外，Na，K-ATP酶还具有受体、信号转导和细胞粘附分子的功能。由于这种不同的作用，可以理解的是，Na，K-ATP酶亚基，催化α-亚基，β-亚基和FXYD蛋白在发育过程中受到广泛控制，以适应生理需要。Na，K-ATP酶的时空表达在转录水平上受到部分调控。许多转录因子、激素、生长因子、脂质和细胞外刺激调节Na，K-ATP酶亚基的转录。此外，表观遗传机制也有助于调节Na，K-ATP酶的表达。随着人们对Na，K-ATP酶功能障碍相关疾病的认识不断深入，本文综述了Na，K-ATP酶亚基水平的转录调控因子。由于Na，K-ATP酶亚基的异常表达已在许多癌症中观察到，我们还将讨论与上皮间质转化相关的转录因子，这是许多肿瘤向恶性疾病进展的关键步骤。
The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion molecule. With such diverse roles, it is understandable that the Na,K-ATPase subunits, the catalytic α-subunit, the β-subunit and the FXYD proteins, are controlled extensively during development and to accommodate physiological needs. The spatial and temporal expression of Na,K-ATPase is partially regulated at the transcriptional level. Numerous transcription factors, hormones, growth factors, lipids, and extracellular stimuli modulate the transcription of the Na,K-ATPase subunits. Moreover, epigenetic mechanisms also contribute to the regulation of Na,K-ATPase expression. With the ever growing knowledge about diseases associated with the malfunction of Na,K-ATPase, this review aims at summarizing the best-characterized transcription regulators that modulate Na,K-ATPase subunit levels. As abnormal expression of Na,K-ATPase subunits has been observed in many carcinoma, we will also discuss transcription factors that are associated with epithelial-mesenchymal transition, a crucial step in the progression of many tumors to malignant disease.