Solifenacin Succinate versus Percutaneous Tibial Nerve Stimulation in Women with Overactive Bladder Syndrome: Results of a Randomized Controlled Crossover Study
Solifenacin Succinate versus Percutaneous Tibial Nerve Stimulation in Women with Overactive Bladder Syndrome: Results of a Randomized Controlled Crossover Study
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DOI：
10.1159/000350216
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发表时间：
2013-01-01
影响因子：
2.1
通讯作者：
Ferrara, Vincenzo
中科院分区：
文献类型：
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作者：
Vecchioli-Scaldazza, Carlo;Morosetti, Carolina;Ferrara, Vincenzo
目的：本研究比较了琥珀酸索利那新（SS）与经皮胫神经刺激（PTNS）治疗膀胱过度活动综合征（OABS）的有效性。方法：对40例OABS妇女进行随机对照交叉研究。患者随机分为两组。A组先予SS，后予PTNS。B组患者先行PTNS，后行SS。在每次治疗前后分别进行排尿日记、生活质量调查和患者紧急程度感知问卷。在研究结束时进行整体印象改善问卷调查。结果：两组患者的每日排尿次数、夜尿和急迫性尿失禁发生率均有所减少，但PTNS的效果优于SS。两组患者的排尿量均有所增加，但PTNS组患者的排尿量增加幅度更大。PTNS在患者感知急迫性和生活质量方面显示出更大的有效性。结论：本研究证实了SS和PTNS治疗膀胱过度活跃症状的有效性。然而，PTNS有更大的改善。巴塞尔S. Karger股份有限公司版权所有
Aims: This study compared the effectiveness of solifenacin succinate (SS) versus percutaneous tibial nerve stimulation (PTNS) in women with overactive bladder syndrome (OABS). Methods: A randomized controlled crossover study of 40 women with OABS was performed. Patients were randomized into two groups. In group A, patients received SS and then PTNS. In group B, patients underwent PTNS and then SS. Voiding diaries, quality of life surveys and patient perception of intensity of urgency questionnaire were performed before and after each treatment. The global impression of improvement questionnaire was performed at the end of the study. Results: A reduction in the number of daily micturitions, episodes of nocturia and urge incontinence were found with both SS and PTNS in all groups, but PTNS showed a greater effectiveness than SS. There was an increase in voided volume in all groups with both SS and PTNS, but patients treated with PTNS had a greater increase. PTNS showed greater effectiveness in patient perception of urgency and quality of life. Condusion: This study demonstrates the effectiveness of SS and PTNS In women with overactive bladder symptoms. However, greater improvements were found with PTNS. Copyright (C) 2013 S. Karger AG, Basel