Surface modification of Si3N4-coated silicon plate for investigation of living cells
Surface modification of Si3N4-coated silicon plate for investigation of living cells
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DOI：
10.1143/jjap.39.6441
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发表时间：
2000-11-01
期刊：
影响因子：
--
通讯作者：
Sugihara, H
中科院分区：
文献类型：
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作者：
Hirata, I;Iwata, H;Sugihara, H
We report a simple new method to improve the cell adhesion ability on the Si3N4 surface. Light-addressable potentiometric sensors (LAPS) have become a powerful tool for studying the biological action of cells. The Si3N4 surface of a LAPS structure was coated with poly-L-ornithine and laminin to improve its cell adhesion ability. The thickness of the coated layer was very thin, about 4 nm, as determined by atomic force. microscopy measurement and thus this treatment surface is suitable for biological sensing applications such as the detection of cell activities.
