Air Pollution Exposure during Pregnancy and Childhood Autistic Traits in Four European Population-Based Cohort Studies: The ESCAPE Project.
Air Pollution Exposure during Pregnancy and Childhood Autistic Traits in Four European Population-Based Cohort Studies: The ESCAPE Project.
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在四项基于欧洲人群的队列研究中，怀孕和儿童自闭症特征期间的空气污染暴露：逃生项目。
DOI：
10.1289/ehp.1408483
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发表时间：
2016-01
影响因子：
10.4
通讯作者：
Sunyer J
中科院分区：
文献类型：
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作者：
Guxens M;Ghassabian A;Gong T;Garcia-Esteban R;Porta D;Giorgis-Allemand L;Almqvist C;Aranbarri A;Beelen R;Badaloni C;Cesaroni G;de Nazelle A;Estarlich M;Forastiere F;Forns J;Gehring U;Ibarluzea J;Jaddoe VW;Korek M;Lichtenstein P;Nieuwenhuijsen MJ;Rebagliato M;Slama R;Tiemeier H;Verhulst FC;Volk HE;Pershagen G;Brunekreef B;Sunyer J
产前暴露于空气污染物已被认为是自闭症谱系障碍发生的一个可能的病因。我们的目的是评估产前空气污染暴露是否与一般人群的儿童自闭症特征有关。我们的研究是一项针对四个欧洲人口出生/儿童队列的合作研究——catss（瑞典）、R世代（荷兰）、GASPII（意大利）和INMA（西班牙）。基于2008年至2011年的监测活动，利用土地利用回归模型估算了出生地址中粒径≤2.5 μm （PM2.5）、≤10 μm （PM10）、2.5 ~ 10 μm （pm粗）的氮氧化物（NO2、NOx）、颗粒物（PM）和PM2.5吸光度。根据准确的怀孕时期推断出的水平。我们定量地评估了孩子在4到10岁之间的自闭症特征。儿童的自闭症特征在边缘/临床范围内分类，并在临床范围内使用有效的切断。调整后的队列特异性效应估计值采用随机效应荟萃分析合并。共纳入8079名儿童。产前空气污染暴露与临界/临床范围内的自闭症特征无关（优势比= 0.94;95% CI: 0.81, 1.10每增加10-μg/m3 NO2妊娠水平）。在不同的队列中观察到类似的结果，对于其他污染物，以及在临床范围内评估具有自闭症特征的儿童或将自闭症特征作为定量评分的儿童。在四项基于欧洲人口的出生/儿童队列研究中，产前暴露于二氧化氮和PM与4至10岁儿童的自闭症特征无关。Guxens M, Ghassabian A, Gong T, Garcia-Esteban R, Porta D, Giorgis-Allemand L, Almqvist C, Aranbarri A, Beelen R, Badaloni C, Cesaroni G, de Nazelle A, Estarlich M, Forastiere F, Forns J, Gehring U, Ibarluzea J, Jaddoe VW, Korek M, Lichtenstein P, Nieuwenhuijsen MJ, Rebagliato M, Slama R, Tiemeier H, Verhulst FC, Volk HE, Pershagen G, Brunekreef B, Sunyer J. 2016。在四个欧洲人群为基础的队列研究中，孕期空气污染暴露和儿童自闭症特征：ESCAPE项目。环境卫生展望124:133-140；http://dx.doi.org/10.1289/ehp.1408483
Prenatal exposure to air pollutants has been suggested as a possible etiologic factor for the occurrence of autism spectrum disorder. We aimed to assess whether prenatal air pollution exposure is associated with childhood autistic traits in the general population. Ours was a collaborative study of four European population-based birth/child cohorts—CATSS (Sweden), Generation R (the Netherlands), GASPII (Italy), and INMA (Spain). Nitrogen oxides (NO2, NOx) and particulate matter (PM) with diameters of ≤ 2.5 μm (PM2.5), ≤ 10 μm (PM10), and between 2.5 and 10 μm (PMcoarse), and PM2.5 absorbance were estimated for birth addresses by land-use regression models based on monitoring campaigns performed between 2008 and 2011. Levels were extrapolated back in time to exact pregnancy periods. We quantitatively assessed autistic traits when the child was between 4 and 10 years of age. Children were classified with autistic traits within the borderline/clinical range and within the clinical range using validated cut-offs. Adjusted cohort-specific effect estimates were combined using random-effects meta-analysis. A total of 8,079 children were included. Prenatal air pollution exposure was not associated with autistic traits within the borderline/clinical range (odds ratio = 0.94; 95% CI: 0.81, 1.10 per each 10-μg/m3 increase in NO2 pregnancy levels). Similar results were observed in the different cohorts, for the other pollutants, and in assessments of children with autistic traits within the clinical range or children with autistic traits as a quantitative score. Prenatal exposure to NO2 and PM was not associated with autistic traits in children from 4 to 10 years of age in four European population-based birth/child cohort studies. Guxens M, Ghassabian A, Gong T, Garcia-Esteban R, Porta D, Giorgis-Allemand L, Almqvist C, Aranbarri A, Beelen R, Badaloni C, Cesaroni G, de Nazelle A, Estarlich M, Forastiere F, Forns J, Gehring U, Ibarluzea J, Jaddoe VW, Korek M, Lichtenstein P, Nieuwenhuijsen MJ, Rebagliato M, Slama R, Tiemeier H, Verhulst FC, Volk HE, Pershagen G, Brunekreef B, Sunyer J. 2016. Air pollution exposure during pregnancy and childhood autistic traits in four European population-based cohort studies: the ESCAPE Project. Environ Health Perspect 124:133–140; http://dx.doi.org/10.1289/ehp.1408483