Nine-Year Incidence and Risk Factors for Retinal Vein Occlusion in a General Japanese Population: The Hisayama Study
Nine-Year Incidence and Risk Factors for Retinal Vein Occlusion in a General Japanese Population: The Hisayama Study
复制标题
DOI：
10.1167/iovs.11-7775
复制
发表时间：
2011-07-01
影响因子：
4.4
通讯作者：
Ishibashi, Tatsuro
中科院分区：
文献类型：
--
作者：
Arakawa, Satoshi;Yasuda, Miho;Ishibashi, Tatsuro
目的.在日本人群队列研究中评估视网膜静脉阻塞（RVO）的长期累积发病率和危险因素。1998年，共有1775名年龄在40岁或以上的人接受了基线眼科检查。其中，1369例受试者（77.1%）在2007年参加了随访眼科检查并入组本研究。每位学员都接受了全面检查。视网膜静脉阻塞（RVO）包括分支静脉阻塞（BRVO）和中央静脉阻塞（CRVO）。进行Logistic回归分析，以确定RVO. ARDS的风险因素。RVO的9年累积发生率为3.0%（BRVO为2.7%，CRVO为0.3%）。年龄特异性RVO累积发病率随年龄增长而显著增加（趋势P = 0.03）。校正年龄和性别后，舒张压升高和慢性肾脏疾病（CKD）与RVO显著相关。在多变量分析中，较高的舒张压（每10 mm Hg）（比值比[OR]，1.51; 95%置信区间[CI]，1.14至2.01）和CKD（OR，2.23; 95% CI，1.02至4.89）仍然是RVO的独立显著风险因素。分层分析显示，无论是非高血压组还是高血压组，CKD患者RVO发生的危险性均高于非CKD患者。这些结果表明，RVO的发病率在日本人高于其他亚洲人和白人，高血压和CKD是RVO的独立危险因素。（Invest Ophthalmol维斯科学。2011;52：5905-5909）DOI：10.1167/iovs.11-7775
PURPOSE. To estimate the long-term cumulative incidence and risk factors for retinal vein occlusion (RVO) in a population-based cohort study of Japanese.METHODS. In 1998, a total of 1775 individuals aged 40 years or older underwent a baseline eye examination. Of those, 1369 subjects (77.1%) took part in the follow-up eye examination in 2007 and were enrolled in the present study. Each participant underwent a comprehensive examination. The diagnosis of RVO, including branch (BRVO) and central RVO (CRVO), was determined by grading color fundus photographs. Logistic regression analysis was performed to determine risk factors for RVO.RESULTS. The 9-year cumulative incidence of RVO was 3.0% (2.7% for BRVO and 0.3% for CRVO). The age-specific cumulative incidence of RVO significantly increased with age (P for trend = 0.03). After adjusting for age and sex, higher diastolic blood pressure and chronic kidney disease (CKD) were significantly associated with RVO. In multivariate analysis, higher diastolic blood pressure (per 10 mm Hg) (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.14 to 2.01) and CKD (OR, 2.23; 95% CI, 1.02 to 4.89) remained independently significant risk factors for RVO. In stratified analysis, the risk of RVO was higher in subjects with CKD than that in subjects without CKD in both the nonhypertension and the hypertension groups.CONCLUSIONS. These findings suggest that the incidence of RVO is higher in Japanese than that in other Asians and Caucasians, and that higher blood pressure and CKD are independent risk factors for RVO in the Japanese. (Invest Ophthalmol Vis Sci. 2011;52:5905-5909) DOI: 10.1167/iovs.11-7775