The Role of Chromatin Structure in Gene Regulation of the Human Malaria Parasite.
The Role of Chromatin Structure in Gene Regulation of the Human Malaria Parasite.
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DOI：
10.1016/j.pt.2016.12.004
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发表时间：
2017-05
影响因子：
9.6
通讯作者：
Le Roch KG
中科院分区：
文献类型：
--
作者：
Batugedara G;Lu XM;Bunnik EM;Le Roch KG
人类疟疾寄生虫恶性疟原虫依靠基因表达的协调调节在人类宿主内发育和繁殖。最近的发展表明，寄生虫的基因调控主要由表观遗传机制控制。在这里，我们讨论了有助于我们理解寄生虫基因调控机制的最新进展，包括核小体景观、组蛋白修饰和核结构。此外，还研究了涉及寄生虫特异性基因和基因家族调节的各种过程。最后，我们解决使用表观遗传过程作为新的抗疟疾疗法的目标。总的来说，这些主题突出了恶性疟原虫的独特生物学，并有助于我们了解这种致命寄生虫调节基因表达的机制。
The human malaria parasite, Plasmodium falciparum, depends on a coordinated regulation of gene expression for development and propagation within the human host. Recent developments suggest that gene regulation in the parasite is largely controlled by epigenetic mechanisms. Here, we discuss recent advancements contributing to our understanding of the mechanisms controlling gene regulation in the parasite, including nucleosome landscape, histone modifications, and nuclear architecture. In addition, various processes involved in regulation of parasite-specific genes and gene families are examined. Finally, we address the use of epigenetic processes as targets for novel antimalarial therapies. Collectively, these topics highlight the unique biology of P. falciparum, and contribute to our understanding of mechanisms regulating gene expression in this deadly parasite.