Eczema and ceramides: an update
Eczema and ceramides: an update
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DOI：
10.1111/cod.12073
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发表时间：
2013-08-01
影响因子：
5.5
通讯作者：
Agner, Tove
中科院分区：
文献类型：
--
作者：
Jungersted, Jakob Mutanu;Agner, Tove
虽然正常的表皮屏障功能取决于许多因素，包括角质层、脂质、酶、pH值和钙梯度，但角质层中的脂质和蛋白质是关键因素。特应性皮炎的特点是屏障异常，例如在近50%的中度/重度特应性皮炎患者中存在聚丝蛋白突变，以及主要表现为神经酰胺不足的脂质紊乱。本文以人体研究为重点，综述了神经酰胺的最新研究进展、神经酰胺在不同类型湿疹中的作用及其治疗方法。我们还考虑了遗传对角质层脂质的影响。这篇综述是对2006年发现特应性皮炎中聚丝蛋白突变后PubMed收录的研究的更新，但当新的出版物不能单独存在时，我们纳入了2006年之前的出版物。
Although normal epidermal barrier function depends on numerous factors, including corneocytes, lipids, enzymes, pH, and calcium gradient, the key players are lipids and proteins in the stratum corneum. Atopic dermatitis is characterized by barrier abnormalities, such as the presence of filaggrin mutations in almost 50% of patients with moderate/severe atopic dermatitis, and lipid disturbances, mainly expressed as insufficient ceramides. In this review, with an emphasis on human studies, we consider the latest research on ceramides, on ceramides in different types of eczema and following various types of treatment. We also consider the genetic influence on stratum corneum lipids. The review is an update on research indexed in PubMed following the discovery of the filaggrin mutations in atopic dermatitis in 2006, but when newer publications cannot stand alone, we include publications from before 2006.