The enzymatic conversion of phospholipid ethanolamine to phospholipid choline in rat liver.
The enzymatic conversion of phospholipid ethanolamine to phospholipid choline in rat liver.
复制标题
大鼠肝脏中磷脂乙醇胺酶促转化为磷脂胆碱。
DOI：
10.1016/s0021-9258(18)64287-5
复制
发表时间：
1961
期刊：
影响因子：
--
通讯作者：
S. Udenfriend
中科院分区：
文献类型：
--
作者：
K. Gibson;J. Wilson;S. Udenfriend
它是从Elwyn et al. (1)在这种物质的从头合成过程中，乙醇胺作为一个单元并入胆碱分子中。Du Vigneaud等人（2，3）表明，胆碱的甲基基团中至少有一些直接来自甲硫氨酸的甲基基团;在早期的交流中，我们提供了所有甲基基团都来自这一来源的证据（4）。最近，作为对大鼠肝脏进行的体内（5）和体外（6，7）研究的结果，Bremer和Greenberg提出胆碱是通过三个甲基从X-腺苷甲硫氨酸逐步转移到磷脂酰乙醇胺而形成的。这里报告的工作基本上证实了他们的发现，并为他们制定的反应提供了一些进一步的支持。4L程序
It is known from the work of Elwyn et al.(1) that ethanolamine is incorporated as a unit into the choline molecule during the synthesis de novo of this substance. Du Vigneaud et al.(2, 3) showed that at least some of the methyl groups of choline are derived directly from the methyl group of methionine; and in an earlier communication we provided evidence that all the methyl groups originate from this source (4). Recently, as a result of studies with rat liver in viva (5) and in vitro (6, 7), Bremer and Greenberg proposed that choline is formed by the stepwise transfer of three methyl groups from X-adenosyl methionine to phosphotidyl ethanolamine. The work reported here essentially confirms their findings and offers some further support for the reactions which they formulated.EXPERIMENT. 4L PROCEDURE