Tumor angiogenesis as a target for dietary cancer prevention.
Tumor angiogenesis as a target for dietary cancer prevention.
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肿瘤血管生成是预防饮食癌的靶标。
DOI：
10.1155/2012/879623
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发表时间：
2012
影响因子：
--
通讯作者：
Chiou AS
中科院分区：
文献类型：
--
作者：
Li WW;Li VW;Hutnik M;Chiou AS
在2000年至2050年期间，每年诊断出的新癌症患者人数预计将增加一倍，在未来十年内，治疗费用将增加800多亿美元。因此，有效的癌症预防策略对于改善患者的生活质量和降低医疗成本至关重要。犹大·福克曼（Judah Folkman）首先提出抗血管生成作为防止休眠微肿瘤进展为侵袭性癌症的策略。尽管抗血管生成药物现在可用于许多晚期恶性肿瘤（结直肠癌、肺癌、乳腺癌、肾癌、肝癌、脑癌、甲状腺癌、神经内分泌癌、多发性骨髓瘤、骨髓增生异常综合征），但成本和毒性因素阻碍了其广泛用于癌症预防。有效的抗血管生成分子现已在饮食来源中被确定，这表明合理设计的抗血管生成饮食可以提供一种安全、广泛可用的预防癌症的新策略。本文介绍了科学，流行病学和临床证据支持的作用，抗血管生成的饮食预防癌症。
Between 2000 and 2050, the number of new cancer patients diagnosed annually is expected to double, with an accompanying increase in treatment costs of more than $80 billion over just the next decade. Efficacious strategies for cancer prevention will therefore be vital for improving patients' quality of life and reducing healthcare costs. Judah Folkman first proposed antiangiogenesis as a strategy for preventing dormant microtumors from progressing to invasive cancer. Although antiangiogenic drugs are now available for many advanced malignancies (colorectal, lung, breast, kidney, liver, brain, thyroid, neuroendocrine, multiple myeloma, myelodysplastic syndrome), cost and toxicity considerations preclude their broad use for cancer prevention. Potent antiangiogenic molecules have now been identified in dietary sources, suggesting that a rationally designed antiangiogenic diet could provide a safe, widely available, and novel strategy for preventing cancer. This paper presents the scientific, epidemiologic, and clinical evidence supporting the role of an antiangiogenic diet for cancer prevention.