Drosophila Arc1 is not required for male fertility or sperm competition success.
Drosophila Arc1 is not required for male fertility or sperm competition success.
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DOI：
10.17912/micropub.biology.001053
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发表时间：
2023
影响因子：
--
通讯作者：
Wolfner, Mariana
中科院分区：
文献类型：
--
作者：
Gordon, Kathleen;Gonzales, Patrick;Lee, Caroline;Marcin, Jeremy;Takashima, Yoko;Lazzaro, Brian;Wolfner, Mariana
活性调节的细胞骨架相关蛋白（Arc1），这是突触可塑性和代谢所需的果蝇，自组装成帽状结构，在细胞外囊泡中运输mRNA。除了在大脑和神经系统中表达外，Arc1还在男性附腺中表达，附腺是一种产生男性精液蛋白和影响男性生育力的外泌体的内皮组织。因此，我们假设Arc1可能会影响男性生育能力。我们测量了生育能力，交配潜伏期，交配持续时间，和精子竞争性能的弧1男性相对于对照组，并没有发现任何证据表明，弧1是需要任何这些措施的男性生育能力。
Activity-regulated cytoskeleton associated protein (Arc1), which is required for synaptic plasticity and metabolism in Drosophila , self-assembles into capsid-like structures that transport mRNAs in extracellular vesicles. In addition to expression in the brain and nervous system, Arc1 is expressed in the male accessory glands, an endothelial tissue that produces male seminal proteins and exosomes that impact male fertility. We thus hypothesized that Arc1 might impact male fertility. We measured the fertility, mating latency, mating duration, and sperm competition performance of Arc1 males relative to controls and found no evidence that Arc1 is required for any of these measures of male fertility.