Feasibility of Using Magnetic Resonance Elastography to Study the Effect of Aging on Shear Modulus of Skeletal Muscle
Feasibility of Using Magnetic Resonance Elastography to Study the Effect of Aging on Shear Modulus of Skeletal Muscle
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DOI：
10.1123/jab.25.1.93
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发表时间：
2009-02-01
影响因子：
1.4
通讯作者：
An, Kai-Nan
中科院分区：
文献类型：
--
作者：
Domire, Zachary J.;McCullough, Matthew B.;An, Kai-Nan
与衰老相关的常见并发症是骨骼肌的硬化。本研究的目的是确定磁共振弹性成像（MRE）在体内研究这种现象的能力。本研究纳入了20例女性受试者，年龄范围为50 - 70岁。计算每个受试者胫骨前肌的剪切模量。年龄与剪切模量之间没有显著的关系。然而，三名受试者的数值异常高，并且是受试者中年龄最大的。年龄与组织硬度均匀性之间存在显著相关性。需要更多的研究来确定这里看到的变化是否反映了组织交联的增加或与肌肉质量降低有关。然而，米泽显示出作为研究与衰老相关的肌肉僵硬变化或评估抵消这些变化的治疗方法的工具的希望。
A common complication associated with aging is the stiffening of skeletal muscles. The purpose of this study was to determine the ability of magnetic resonance elastography (MRE) to study this phenomenon in vivo. Twenty female subjects were included in the study with an age range of 50 to 70 years. Shear modulus was calculated for the tibialis anterior of each subject. There was not a significant relationship between age and shear modulus. However, three subjects had abnormally high values and were among the oldest subjects tested. There was a significant relationship between age and tissue stiffness homogeneity. More research is needed to determine whether the changes seen here are reflective of increased tissue cross-linking or related to reduced muscle quality. However, MIZE shows promise as a tool to study aging-related muscle stiffness changes or to evaluate treatments to counteract these changes.