Vitamin D and Heart Failure.
Vitamin D and Heart Failure.
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DOI：
10.1007/s11897-017-0355-7
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发表时间：
2017-10-01
影响因子：
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通讯作者：
Wang, Thomas J
中科院分区：
文献类型：
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作者：
Brinkley, D Marshall;Ali, Omair M;Wang, Thomas J
目得：维生素D主要以其在钙稳态中的作用而闻名，但临床前研究表明，维生素D可能通过多种途径影响心血管功能并影响心力衰竭的风险。许多患有心血管疾病的成年人维生素D水平较低，使其成为潜在的治疗靶点。我们审查的基本原理和潜在的作用，维生素D补充剂在预防和治疗慢性heartfault.Recent发现：大量的观察证据表明，低维生素D状态与心力衰竭的风险，心室重塑，心力衰竭的临床结局，包括死亡率。然而，评估补充维生素D对心力衰竭替代标志物和临床结局影响的试验通常规模较小且不确定。没有足够的数据推荐常规评估或补充维生素D以预防或治疗慢性心力衰竭。有必要进行前瞻性临床试验。
PURPOSE: Vitamin D is principally known for its role in calcium homeostasis, but preclinical studies implicate multiple pathways through which vitamin D may affect cardiovascular function and influence risk for heart failure. Many adults with cardiovascular disease have low vitamin D status, making it a potential therapeutic target. We review the rationale and potential role of vitamin D supplementation in the prevention and treatment of chronic heart failure.RECENT FINDINGS: Substantial observational evidence has associated low vitamin D status with the risk of heart failure, ventricular remodeling, and clinical outcomes in heart failure, including mortality. However, trials assessing the influence of vitamin D supplementation on surrogate markers and clinical outcomes in heart failure have generally been small and inconclusive. There are insufficient data to recommend routine assessment or supplementation of vitamin D for the prevention or treatment of chronic heart failure. Prospective trials powered for clinical outcomes are warranted.