Water-Enabled H2 Generation from Hydrogenated Silicon Nanosheets for Efficient Anti-Inflammation.
Water-Enabled H2 Generation from Hydrogenated Silicon Nanosheets for Efficient Anti-Inflammation.
复制标题
DOI：
10.1021/jacs.2c04412
复制
发表时间：
2022-07
影响因子：
15
通讯作者：
Y. You;Yanong Zhu;Junjie Jiang;Min Wang;Zhixin Chen;Chenyao Wu;Jie Wang;Wujie Qiu;Deliang Xu
中科院分区：
文献类型：
--
作者：
Y. You;Yanong Zhu;Junjie Jiang;Min Wang;Zhixin Chen;Chenyao Wu;Jie Wang;Wujie Qiu;Deliang Xu
氢(H2)是一种新兴的治疗气体，具有良好的生物安全性、高组织渗透性和捕捉自由基的能力，被广泛认为是一种非常有前途的临床抗氧化剂。然而，用于治疗主要炎症性疾病的简便而有效的制氢策略仍然缺乏。本研究采用湿法化学剥离法制备了一种氢封端的纳米硅片(H-硅烯)，它可以在不需要任何外部能量输入的情况下，与环境中的水快速、连续地反应生成氢气。此外，通过理论计算揭示了H-硅烯纳米片提高产氢效率的机理。合成的氢硅烯首次被探索作为一种灵活的氢气发生器，用于有效的抗氧化应激应用，这突显了这种二维氢硅烯纳米材料通过按需产生氢气使能清除活性氧物种来治疗急性炎症的前景。本研究为纳米材料介导的氢气治疗提供了一种新的有效途径。
As an emerging therapeutic gas, hydrogen (H2) is gifted with excellent biosafety, high tissue permeability, and radical-trapping capacity and is extensively considered as a highly promising antioxidant in clinics. However, a facile and effective strategy of H2 production for major inflammatory disease treatments is still lacking. In this study, by a facile wet-chemical exfoliation synthesis, a hydrogen-terminated silicon nanosheet (H-silicene) has been synthesized, which can favorably react with environmental water to generate H2 rapidly and continuously without any external energy input. Furthermore, theoretical calculations were employed to reveal the mechanism of enhanced H2 generation efficacy of H-silicene nanosheets. The as-synthesized H-silicene has been explored as a flexible hydrogen gas generator for efficient antioxidative stress application for the first time, which highlights a promising prospect of this two-dimensional H-silicene nanomaterial for acute inflammatory treatments by on-demand H2 production-enabled reactive oxygen species scavenging. This study provides a novel and efficient modality for nanomaterial-mediated H2 therapy.