Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice
Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice
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DOI：
10.1038/ismej.2017.24
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发表时间：
2017-07-01
期刊：
影响因子：
11
通讯作者：
Pekkala, Satu
中科院分区：
文献类型：
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作者：
Munukka, Eveliina;Rintala, Anniina;Pekkala, Satu
普氏粪杆菌被认为是健康肠道最重要的细菌指标之一。我们研究了口服F。prausnitzii治疗对高脂肪喂养的小鼠。与高脂对照组相比，F。普拉氏菌处理的小鼠具有较低的肝脂肪含量、天冬氨酸氨基转移酶和丙氨酸氨基转移酶，并且增加了肝脏中的脂肪酸氧化和脂联素信号传导。肝脏脂质组学分析显示几种甘油三酯、磷脂和胆固醇酯减少。内脏脂肪组织脂联素表达增加，皮下和内脏脂肪组织对胰岛素更敏感，炎症更少。prausnitzii处理的小鼠。此外，F. prausnitzii治疗增加了肌肉质量，这可能与增强的线粒体呼吸、改变的肠道微生物群组成和改善的肠道完整性有关。结果表明，F. Prausnitzii治疗改善了小鼠的肝脏健康，并减少了脂肪组织炎症，需要进一步研究以发现其治疗潜力。
Faecalibacterium prausnitzii is considered as one of the most important bacterial indicators of a healthy gut. We studied the effects of oral F. prausnitzii treatment on high-fat fed mice. Compared to the high-fat control mice, F. prausnitzii-treated mice had lower hepatic fat content, aspartate aminotransferase and alanine aminotransferase, and increased fatty acid oxidation and adiponectin signaling in liver. Hepatic lipidomic analyses revealed decreases in several species of triacylglycerols, phospholipids and cholesteryl esters. Adiponectin expression was increased in the visceral adipose tissue, and the subcutaneous and visceral adipose tissues were more insulin sensitive and less inflamed in F. prausnitzii-treated mice. Further, F. prausnitzii treatment increased muscle mass that may be linked to enhanced mitochondrial respiration, modified gut microbiota composition and improved intestinal integrity. Our findings show that F. prausnitzii treatment improves hepatic health, and decreases adipose tissue inflammation in mice and warrant the need for further studies to discover its therapeutic potential.