Explore the role of CR1 genetic variants in late-onset Alzheimer's disease susceptibility
Explore the role of CR1 genetic variants in late-onset Alzheimer's disease susceptibility
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DOI：
10.1097/ypg.0000000000000291
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发表时间：
2021-12-01
影响因子：
0.9
通讯作者：
Zhu, Xi-Chen
中科院分区：
文献类型：
--
作者：
Lu, Liu;Yao, Qing-Yu;Zhu, Xi-Chen
背景补体成分（3b/4b）受体1（CR1）是一个有趣的候选基因，与阿尔茨海默病密切相关，据报道其多态性与晚发型阿尔茨海默病（LOAD）易感性有关。然而，这些相关研究的结果并不一致。目的探讨CR1基因变异对LOAD易感性的影响。方法 我们检索了截至 2020 年 11 月 1 日期间的相关研究。并利用比值比 (OR) 及其 95% 置信区间 (Cis) 来评估关联的强度。此外，我们还进行了病例对照关联研究来评估其遗传关联。结果最终共纳入 30 篇文章，其中 30108 个 LOAD 病例和 37895 个对照。在 rs3818361 和 rs6656401 中观察到 LOAD 患者和对照之间存在显着的等位基因频率（rs3818361，T 与 C：OR.1.18；95% CI，1.13-1.23；rs6656401。A 与 G：OR，1.23；95% CI，1.10-1.36）。此外，这些结果在亚洲或美洲的 rs3818361 亚组（OR，1.26；95% CI，1.06-1.45；OR，1.18；95% CI，1.13-1.24）和欧洲的 rs6656401 亚组（OR=1.26；95% CI，1.09-1.42）中仍然显着。此外，两种单核苷酸多态性被证明在主导模型下显着增加总体人群的LOAD风险（OR=1.12；95%CI，1.02±1.21；OR=1.18，95%CI，1.15-1.22）。我们的病例对照研究表明，rs6656401基因型的分布显着（P=0.000；OR，6.889；95% CI，2.709-17.520），表明rs6656401的A等位基因是风险等位基因。 结论 这些现有数据表明，CR1中的rs6656401对增加LOAD风险具有显着意义。版权所有 (C) 2021 Wolters Kluwer Health, Inc. 保留所有权利。
Background Complement component (3b/4b) receptor 1 (CR1) is an interesting candidate gene which has a close connection with Alzheimer's disease, and its polymorphisms have been reported to link to the lateonset Alzheimer's disease (LOAD) susceptibility. However, the findings of these related studies are inconsistent. Objective To explore the effect of CR1 genetic variants in LOAD susceptibility. Methods We searched relevant studies for the period up to 1 November 2020. And odds ratios (ORs) and their 95% confidence intervals (Cis) were utilized to assess the strength of the association. In addition, we carried out a case-control association study to assess their genetic association.Results Finally, a total of 30 articles with 30108 LOAD cases and 37895 controls were included. Significant allele frequency between LOAD patients and controls was observed in rs3818361 and rs6656401 (rs3818361, T vs. C: OR.1.18; 95% CI, 1.13-1.23; rs6656401. A vs. G: OR, 1.23; 95% CI, 1.10-1.36). Moreover, these results remain significant in subgroup of rs3818361 in Asia or America (OR,1.26; 95% CI,1.06-1.45; OR, 1.18; 95% CI, 1.13-1.24, respectively) and rs6656401 in Europe (OR=1.26; 95% CI, 1.09-1.42). In addition, the two single nucleotide polymorphisms were proved to significantly increase LOAD risk in the overall population under the dominant model (OR= 1.12; 95% CI, 1.02 1.21; OR=1.18, 95% CI, 1.15-1.22, respectively). Our case-control study showed that the distribution of rs6656401 genotype was significant (P=0.000; OR, 6.889; 95% CI, 2.709-17.520), suggesting the A allele of rs6656401 is the risk allele.Conclusion These available data indicate that rs6656401 in CR1 is significant to increase LOAD risk. Copyright (C) 2021 Wolters Kluwer Health, Inc. All rights reserved.