Dietary risk factors for nasopharyngeal carcinoma in Maghrebian countries
Dietary risk factors for nasopharyngeal carcinoma in Maghrebian countries
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DOI：
10.1002/ijc.22813
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发表时间：
2007-10-01
影响因子：
6.4
通讯作者：
Corbex, Marilys
中科院分区：
文献类型：
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作者：
Feng, Bing-Jian;Jalbout, Majida;Corbex, Marilys
北非是鼻咽癌（NPC）主要流行地区之一。该地区特有的特定食品与鼻咽癌风险相关，但结果不一致。在这里，我们对突尼斯、阿尔及利亚和摩洛哥的马格里布人群进行了大规模病例对照研究。从2002年到2005年，对636个病例和615个对照进行了访谈。对照是来自 15 个非癌症医院科室的住院患者，或非 NPC 癌症受试者的朋友和家人，按中心、儿童家庭类型（农村或城市）、年龄和性别进行匹配。条件逻辑回归用于评估因素的风险。结果显示，食用腐臭黄油、腐臭羊脂和不辣的腌肉（主要是四肢肉）与鼻咽癌风险显着增加相关，而食用煮熟的蔬菜和工业腌制鱼则与鼻咽癌风险降低相关。其他食物，如童年时的新鲜柑橘类水果和辛辣腌制食品（主要是奥斯班），成年时工业生产的橄榄调味品，则有一定的相关性。在多变量分析中，只有腐臭黄油、腐臭羊脂和煮熟的蔬菜与鼻咽癌显着相关。关于可能的致病物质，我们的结果表明丁酸参与其中，丁酸是一种潜在的 Epstein-Barr 病毒 (EBV) 激活剂。 (C) 2007 Wiley-Liss, Inc.
North Africa is one of the major Nasopharyngeal Carcinoma (NPC) endemic regions. Specific food items unique to this area were implicated to be associated with NPC risk, but results were inconsistent. Here we have performed a large-scale case-control study in the Maghrebian population from Tunisia, Algeria and Morocco. From 2002 to 2005, interviews were conducted on 636 cases and 615 controls. Controls were hospitalized individuals from 15 non-cancer hospital departments, or friends and family members of non-NPC cancer subjects, matched by center, childhood household type (rural or urban), age and sex. Conditional logistic regression is used to evaluate the risk of factors. In results, consumption of rancid butter, rancid sheep fat and preserved meat not spicy (mainly quaddid) were associated with significantly increased risk of NPC, while consumption of cooked vegetables and industrial preserved fish was associated with reduced risk. Other foods such as fresh citrus fruits and spicy preserved me., (mainly osban) in childhood, industrial made olive condiments in adulthood, were marginally associated. In multivariate analyses, only rancid butter, rancid sheep fat and cooked vegetables were significantly associated with NPC. In regard to possible causative substances, our results implicate the involvement of butyric acid, a potential Epstein-Barr virus (EBV) activator. (C) 2007 Wiley-Liss, Inc.