Optical biopsy in human urologic tissue using optical coherence tomography
Optical biopsy in human urologic tissue using optical coherence tomography
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DOI：
10.1016/s0022-5347(01)64900-0
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发表时间：
1997-05-01
影响因子：
6.6
通讯作者：
Fujimoto, JG
中科院分区：
文献类型：
--
作者：
Tearney, GJ;Brezinski, ME;Fujimoto, JG
光学相干层析成像(OCT)是最近发展起来的一种非侵入性技术，用于获得人体组织的高分辨率横断面图像。本研究探讨OCT鉴别泌尿系统组织结构形态的能力，以期将OCT用作内窥镜成像的辅助手段，并提高经尿道前列腺切除术(TURF)等介入性手术的效率。死后取尿路组织，用OCT进行解剖和成像。在不同的泌尿系统组织中，包括前列腺、前列腺、膀胱和输尿管，显微结构被描绘出来，其轴向分辨率为16+/-µm，高于任何临床可用的内窥镜腔内成像技术。OCT能够提供泌尿系统组织结构形态的非接触式高分辨率成像(即光学活检)，而不需要切除活检，这表明使用OCT获得以前只能通过传统活检获得的组织微结构信息的潜力。
Optical Coherence Tomography (OCT) is a recently developed non-invasive technique for obtaining high resolution, cross-sectional images of human tissue. This work investigated the capability of OCT to differentiate the architectural morphology of urologic tissue with the long term aim of using OCT as an adjunct to endoscopic imaging and to improve the efficiency of interventional procedures such as transurethral prostatectomy (TURF). Urologic tissues were taken postmortem, dissected, and imaged using OCT. Microstructure was delineated in different urologic tissues, including the prostatic urethra, prostate, bladder, and ureter, with an axial resolution of 16 +/- mu m., higher than any clinically available endoscopic intraluminal imaging technology. The ability of OCT to provide non-contact high resolution imaging of urologic tissue architectural morphology (i.e. optical biopsy), without the need for excisional biopsy, suggests the potential of using OCT to obtain information on tissue microstructure that could only previously be obtained with conventional biopsy.