Antiproliferative effect of dietary glucarate on the Sprague-Dawley rat mammary gland.
Antiproliferative effect of dietary glucarate on the Sprague-Dawley rat mammary gland.
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膳食葡萄糖二酸盐对斯普拉格-道利大鼠乳腺的抗增殖作用。
DOI：
10.1016/0304-3835(90)90138-n
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发表时间：
1990
期刊：
影响因子：
9.7
通讯作者：
Adams,AK
中科院分区：
文献类型：
--
作者：
Walaszek,Z;Hanausek,M;Sherman,U;Adams,AK
此前已证明膳食葡萄糖二酸盐可抑制化学致癌物诱导的大鼠乳腺肿瘤发生。本文证明，在雌性Sprague-Dawley大鼠的乳腺中，从35日龄开始以70 mmol/kg AIN-76 A饲料的剂量饲喂葡萄糖二酸盐2周，显著降低[3 H]胸苷标记。使用β-葡萄糖醛酸酶的特异性组织化学染色显示，向大鼠饲喂葡萄糖二酸盐饲料2-4周可抑制乳腺中的β-葡萄糖醛酸酶活性，并对乳腺上皮具有显著的抗增殖作用。葡萄糖二酸盐可能部分通过改变靶器官的增殖状态来抑制大鼠乳腺癌的发生。
Dietary glucarate has previously been shown to inhibit chemical carcinogen-induced rat mammary tumorigenesis. It is demonstrated in this paper that in the mammary gland of the female Sprague-Dawley rat, feeding glucarate at a dose of 70 mmol/kg AIN-76A diet for 2 weeks beginning at 35 days of age, markedly reduces [3H]thymidine labeling. Specific histochemical staining for β-glucuronidase is used to show that the glucarate diet fed to rats for 2–4 weeks inhibits β-glucuronidase activity in the mammary gland and has a marked antiproliferative effect on mammary epithelium. Glucarate may inhibit rat mammary carcinogenesis, in part, by changing the proliferative status of the target organ.