Toward site-specific, homogeneous and highly stable fluorescent silver nanoclusters fabrication on triplex DNA scaffolds
Toward site-specific, homogeneous and highly stable fluorescent silver nanoclusters fabrication on triplex DNA scaffolds
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在三链 DNA 支架上实现位点特异性、均质且高度稳定的荧光银纳米簇制造
DOI：
10.1093/nar/gks387
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发表时间：
2012-09-01
影响因子：
14.9
通讯作者：
Qu, Xiaogang
中科院分区：
文献类型：
--
作者：
Feng, Lingyan;Huang, Zhenzhen;Qu, Xiaogang
以三链体DNA为模板制备了具有位点特异性、均一性和高稳定性的光亮银纳米团簇（AgNC）。通过合理的DNA序列设计，在三链DNA的CG.C+位点的预定位置获得了均一的Ag 2簇。还探索了这种策略用于DNA纳米支架上AgNC的受控比对。据我们所知，这是第一个同时解决DNA模板化AgNC的优异位点特异性成核和生长、均一性和盐稳定性的挑战的例子。
A new strategy to create site-specific, homogeneous, and bright silver nanoclusters (AgNCs) with high-stability was demonstrated by triplex DNA as template. By reasonable design of DNA sequence, homogeneous Ag2 cluster was obtained in the predefined position of CG.C+ site of triplex DNA. This strategy was also explored for controlled alignment of AgNCs on the DNA nanoscaffold. To the best of our knowledge, this was the first example to simultaneously answer the challenges of excellent site-specific nucleation and growth, homogeneity and stability against salt of DNA-templated AgNCs.