Rabs set the stage for polarity.
Rabs set the stage for polarity.
复制标题
拉布斯为极性奠定了基础。
DOI：
10.1080/21541248.2016.1277840
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Wilson,JeanM
中科院分区：
文献类型：
--
作者：
Parker,SaraS;Cox,Christopher;Wilson,JeanM
细胞极性是指允许细胞执行其专门功能的细胞组分的不对称定位，无论是上皮屏障功能、神经细胞中动作电位的传递还是免疫应答的调节。细胞极性的建立和维持需要膜蛋白和脂质的定向运输-这是由Rab GTP酶介导的基本过程。有趣的是，一些影响极性的Rab存在于最早的真核生物中，随着细胞变得更加复杂，Rab极性库已经扩大。在不同的细胞类型中，Rab功能有很大的保守性。Rabs通过各种效应蛋白发挥作用，包括支架蛋白、细胞骨架马达和其他小GTP酶。在这篇综述中，我们强调了Rab功能的相似性和差异，在不同的细胞类型的极性指令。
Cell polarity refers to the asymmetric localization of cellular components that allows cells to carry out their specialized functions, be they epithelial barrier function, transmission of action potentials in nerve cells, or modulation of the immune response. The establishment and maintenance of cell polarity requires the directed trafficking of membrane proteins and lipids - essential processes that are mediated by Rab GTPases. Interestingly, several of the Rabs that impact polarity are present in the earliest eukaryotes, and the Rab polarity repertoire has expanded as cells have become more complex. There is a substantial conservation of Rab function across diverse cell types. Rabs act through an assortment of effector proteins that include scaffolding proteins, cytoskeletal motors, and other small GTPases. In this review we highlight the similarities and differences in Rab function for the instruction of polarity in diverse cell types.