Cholinergic modulation of hippocampal network function.
Cholinergic modulation of hippocampal network function.
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DOI：
10.3389/fnsyn.2013.00002
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发表时间：
2013
影响因子：
3.7
通讯作者：
Mellor JR
中科院分区：
文献类型：
--
作者：
Teles-Grilo Ruivo LM;Mellor JR
从内侧隔区到海马区的胆碱能隔区投射被认为通过调节海马网的特性在认知中发挥重要作用。然而，海马区乙酰胆碱释放的精确时空分布仍然不清楚，这使得很难确定胆碱能传递在海马区依赖行为中的具体作用。这在一定程度上是由于缺乏能够对胆碱能传递进行特定干预和记录的工具。在这里，我们回顾了隔-海马胆碱能投射和海马乙酰胆碱受体的组织，以及胆碱能传递在调节细胞兴奋性、突触可塑性和节律性网络振荡中的作用。我们指出了一些悬而未决的问题，并讨论了最近开发的技术的可能性，以提供对海马体胆碱能输入功能的根本性重新评估。
Cholinergic septohippocampal projections from the medial septal area to the hippocampus are proposed to have important roles in cognition by modulating properties of the hippocampal network. However, the precise spatial and temporal profile of acetylcholine release in the hippocampus remains unclear making it difficult to define specific roles for cholinergic transmission in hippocampal dependent behaviors. This is partly due to a lack of tools enabling specific intervention in, and recording of, cholinergic transmission. Here, we review the organization of septohippocampal cholinergic projections and hippocampal acetylcholine receptors as well as the role of cholinergic transmission in modulating cellular excitability, synaptic plasticity, and rhythmic network oscillations. We point to a number of open questions that remain unanswered and discuss the potential for recently developed techniques to provide a radical reappraisal of the function of cholinergic inputs to the hippocampus.