Immunometabolic biomarkers of inflammation in Behcet's disease: relationship with epidemiological profile, disease activity and therapeutic regimens
Immunometabolic biomarkers of inflammation in Behcet's disease: relationship with epidemiological profile, disease activity and therapeutic regimens
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DOI：
10.1111/cei.12768
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发表时间：
2016-05-01
影响因子：
4.6
通讯作者：
Matarese, G.
中科院分区：
文献类型：
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作者：
Cantarini, L.;Pucino, V.;Matarese, G.
白塞病(BD)是一种全身性炎症性疾病，发病机制尚不清楚。虽然已经研究了几种炎症分子，但目前的生物标志物在BD中很大程度上不敏感，无法预测疾病的进展和治疗反应。探讨27例BD患者血清可溶性CD40L、可溶性细胞间黏附分子(sICAM-1)、单核细胞趋化蛋白-1(MCP-1)、髓过氧化物酶(MPO)、瘦素、抵抗素、护骨素、可溶性1型肿瘤坏死因子受体(STNFR)、白介素6(IL-6)和血清淀粉样蛋白A(SAA)的水平。第二个目的是评估假定的循环生物标志物、患者的人口学特征、疾病活动状态、样本采集时特定器官受累以及不同治疗方案之间的潜在相关性。血清sTNFR(P=00011)、瘦素(P=0.000)、sCD40L(P
Behcet's disease (BD) is a systemic inflammatory disease with a still unclear pathogenesis. Although several inflammatory molecules have been studied, current biomarkers are largely insensitive in BD and unable to predict disease progression and response to treatment. Our primary aim was to explore serum levels of soluble CD40 L (sCD40L), soluble intracellular adhesion molecule (sICAM-1), monocyte chemoattractant protein-1 (MCP-1), myeloperoxidase (MPO), leptin, resistin, osteoprotegerin (OPG), soluble type 1 tumour necrosis factor receptor (sTNFR), interleukin (IL)-6 and serum amyloid A (SAA) serum concentration in a cohort of 27 BD patients. The secondary aim was to evaluate potential correlations between the putative circulating biomarkers, demographic profile of patients, the status of disease activity, the specific organ involvement at the time of sample collection and different therapeutic regimens. Serum concentrations of sTNFR (P=0008), leptin (P=00011), sCD40L (P