Results of diagnostic investigations and long-term outcome of 33 dogs with brain infarction (2000-2004)
Results of diagnostic investigations and long-term outcome of 33 dogs with brain infarction (2000-2004)
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DOI：
10.1892/0891-6640(2005)19
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发表时间：
2005-09-01
影响因子：
2.6
通讯作者：
Schatzberg, SJ
中科院分区：
文献类型：
--
作者：
Garosi, L;McConnell, JF;Schatzberg, SJ
回顾了33只急性发作、非进展性、颅内功能障碍的犬的病历，这些犬的磁共振成像诊断为脑梗死。10只犬尸检证实脑梗死。通过CBC、血清生化、甲状腺和肾上腺检测、尿液分析、胸部和腹部成像以及脑脊液分析对所有犬进行评价。分别在32/33和28/33只犬中获得凝血特征和动脉血压结果。根据影像学检查结果，根据梗死类型（区域性或腔隙性）和脑内位置（端脑，10/33;丘脑/中脑，8/33;小脑，15/33）对梗死进行分类。位置或类型之间没有明显的关联。确定了梗死的发生率、患者的年龄和性别、全身性高血压的发生率以及是否存在并发的医学疾病。小型犬（15 kg）更容易发生腔隙性丘脑或中脑梗死。在18/33只脑梗死犬中检测到并发疾病，最常见的是慢性肾病（8/33）和肾上腺皮质功能亢进（6/ 33）。在33只狗中，有10只因其神经状态的严重性和缺乏改善或并发疾病的严重性而被安乐死。梗死类型或部位与患者预后之间无相关性。并发医疗条件的狗有显着较短的生存时间比那些没有可识别的医疗条件，并显着更容易遭受复发的神经系统症状，因为随后的梗死。
Medical records of 33 dogs presented for acute onset, nonprogressive, intracranial dysfunction that had a magnetic resonance imaging diagnosis of brain infarction were reviewed. Postmortem confirmation of brain infarction was available in 10 dogs. All dogs were evaluated by CBC, serum biochemistry, thyroid and adrenal testing, urinalysis, thoracic and abdominal imaging, and cerebrospinal fluid analysis. Results of coagulation profile and arterial blood pressure were available in 32/33 and 28/33 dogs, respectively. On the basis of the imaging findings, infarcts were classified depending on their type (territorial or lacunar) and location within the brain (telencephalic, 10/33; thalamic/midbrain, 8/33; cerebellar, 15/33). No marked associations among location or type. of infarct and patient age and sex, occurrence of systemic hypertension, and the presence or absence of a concurrent medical condition were identified. Small breed dogs ( 15 kg) were significantly more likely to have lacunar thalamic or midbrain infarcts. A concurrent medical condition was detected in 18/33 dogs with brain infarcts, with chronic kidney disease (8/33) and hyperadrenocorticism (6/ 33) being most commonly encountered. Of 33 dogs, 10 were euthanized because of the severity and lack of improvement of their neurologic status or the severity of their concurrent medical condition. No association was identified between type or location of infarct and patient outcome. Dogs with concurrent medical conditions had significantly shorter survival times than those with no identifiable medical condition and were significantly more likely to suffer from recurrent neurologic signs because of subsequent infarcts.