A practical experiment to teach students continuous flow and physico-chemical methods: acetylation of ethylene diamine in liquid bi-phase
A practical experiment to teach students continuous flow and physico-chemical methods: acetylation of ethylene diamine in liquid bi-phase
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DOI：
10.1007/s41981-020-00114-5
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发表时间：
2020-09-11
影响因子：
2.7
通讯作者：
Reynolds, William
中科院分区：
文献类型：
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作者：
Bayana, Mary;Blacker, A. John;Reynolds, William
尽管在学术界和工业界都有越来越多的应用报道，但连续流化学仍然是大多数化学本科课程中相对无人教授的领域。在实验室实践课程中尤其如此，在那里通常认为使用圆底烧瓶以传统的分批模式进行合成反应更简单。在此，我们报告了一个本科项目的发展，利用廉价和容易获得的材料来构建连续流反应器。学生们比较了不同类型的反应器和对称二胺的两相选择性乙酰化条件的性能。在整个调查过程中，学生可以改变多个参数，因为他们优化的反应，从而积极学习和调整他们的基础上提高理解。这些实验使学生们对连续流技术与间歇流技术进行了比较。
Despite growing applications being reported both in academia and industry, continuous flow chemistry remains a relatively untaught field across most chemistry undergraduate courses. This is particularly true in laboratory practical classes, where it is often deemed simpler to carry out synthetic reactions in traditional batch mode using round-bottomed flasks. Herein, we report the development of an undergraduate project that utilises cheap and readily available materials to construct continuous flow reactors. The students compare the performance of different types of reactors and conditions in a biphasic selective acetylation of a symmetrical diamine. Throughout the investigation, the students can vary multiple parameters as they optimise the reaction, thus actively learning and readjusting them based on their improved understanding. The experiments give the students an appreciation of continuous flow techniques in comparison to batch.