Electrocardiographic left ventricular hypertrophy cornell product is a feasible predictor of cardiac prognosis in patients with chronic heart failure.
Electrocardiographic left ventricular hypertrophy cornell product is a feasible predictor of cardiac prognosis in patients with chronic heart failure.
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心电图左心室肥厚康奈尔产品是慢性心力衰竭患者心脏预后的可行预测因子。
DOI：
10.1007/s00392-013-0646-2
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Kubota I
中科院分区：
文献类型：
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作者：
Otaki Y;Takahashi H;Watanabe T;Kadowaki S;Narumi T;Honda Y;Hasegawa H;Honda S;Funayama A;Nishiyama;Arimoto T;Shishido T;Miyashita T;Miyamoto T;Kubota I
背景左心室肥厚(LVH)是心血管疾病的独立危险因素，与心力衰竭的发生有关。康奈尔产品是一种易于测量的评估左心室肥厚的心电图学参数。然而，康奈尔乘积是否能够预测慢性心力衰竭(CHF)患者的心脏预后尚不确定。方法和结果我们对连续432名CHF患者进行了标准12导联心电图检查，并计算了康奈尔乘积。评价左室构型为正常、向心性重构、向心性或偏心性肥厚。在偏心性肥厚的患者中，康奈尔的产品显著更高，并且随着纽约心脏协会功能分级的提高而增加。在660天的中位随访期间，发生了121起心脏事件，包括36例心脏病死亡和85例因心力衰竭恶化而再次住院。多变量COX比例风险分析显示，康奈尔乘积是CHF患者心脏事件的独立预测因子。康奈尔产品中最高四分位数的患者左室离心性肥厚的发生率较高(四分位数1至4分位数分别为22%、29%、33%和67%)。Kaplan-Meier分析表明，在CHF患者中，康奈尔乘积的最高四分位数与最大的风险相关。结论康奈尔乘积与左室离心性肥厚有关，可用于预测CHF患者未来的心脏事件。
BackgroundLeft ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular disease and is associated with heart failure development. The Cornell product is an easily measured electrocardiographic parameter for assessing LVH. However, it is undetermined whether the Cornell product can predict the cardiac prognosis of chronic heart failure (CHF) patients.Methods and resultsWe performed standard 12-lead electrocardiography and calculated the Cornell product in 432 consecutive CHF patients. LV geometry was assessed as normal, concentric remodeling, concentric or eccentric hypertrophy. The Cornell product was significantly higher in patients with eccentric hypertrophy, and increased with advancing New York Heart Association functional class. During a median follow-up of 660 days, there were 121 cardiac events including 36 cardiac deaths and 85 re-hospitalizations for worsening heart failure. Multivariate Cox proportional hazard analysis showed that the Cornell product was an independent predictor of cardiac events in CHF patients. Patients in the highest quartile of Cornell product had a higher prevalence of LV eccentric hypertrophy (22, 29, 33 and 67 % for quartiles one through four). Kaplan–Meier analysis demonstrated that the highest quartile of Cornell product was associated with the greatest risk among CHF patients.ConclusionThe Cornell product is associated with LV eccentric hypertrophy and can be used to predict future cardiac events in CHF patients.