CAFFEINE EFFECTS ON CARDIOVASCULAR AND NEUROENDOCRINE RESPONSES TO ACUTE PSYCHOSOCIAL STRESS AND THEIR RELATIONSHIP TO LEVEL OF HABITUAL CAFFEINE CONSUMPTION
CAFFEINE EFFECTS ON CARDIOVASCULAR AND NEUROENDOCRINE RESPONSES TO ACUTE PSYCHOSOCIAL STRESS AND THEIR RELATIONSHIP TO LEVEL OF HABITUAL CAFFEINE CONSUMPTION
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DOI：
10.1097/00006842-199005000-00006
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发表时间：
1990-05-01
影响因子：
3.3
通讯作者：
KUHN, CM
中科院分区：
文献类型：
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作者：
LANE, JD;ADCOCK, RA;KUHN, CM
：在 25 名习惯或轻度饮用咖啡因的健康男性受试者中，研究了中等剂量的咖啡因对心血管和神经内分泌应激反应的影响。测量是在服用咖啡因（3.5 mg/kg）或安慰剂之前和之后、在有压力的实验室任务期间以及在压力后恢复期间的静息条件下进行的。咖啡因会升高静息时的血压和血浆去甲肾上腺素水平，从而显着增加压力的影响。咖啡因会增强与应激相关的血浆肾上腺素和皮质醇应激的增加，使对照条件下观察到的反应增加一倍以上。这些影响在习惯性和轻度消费者中都存在，并且习惯性咖啡因摄入量并不影响其程度。结果表明，咖啡因可以增强心血管和神经内分泌应激反应性，并且习惯性使用咖啡因不一定与对这些作用的耐受性的发展相关。
: The effects of a moderate dose of caffeine on cardiovascular and neuroendocrine stress reactivity were examined in 25 healthy male subjects selected as habitual or light consumers of caffeine. Measurements were taken under resting conditions before and after administration of caffeine (3.5 mg/kg) or placebo, during a stressful laboratory task, and in a post-stress recovery period. Caffeine elevated blood pressure and plasma norepinephrine levels at rest, effects which added significantly to the effects of stress. Caffeine potentiated stress-related increases in plasma epinephrine and cortisol stress, more than doubling the responses observed in the control condition. These effects were present in both habitual and light consumers and level of habitual caffeine consumption did not affect their magnitude. Results indicate that caffeine can potentiate both cardiovascular and neuroendocrine stress reactivity and that the habitual use of caffeine is not necessarily associated with the development of tolerance to these effects.