Microfluidics as A Tool to Understand the Build-Up Mechanism of Exponential-Like Growing Films
Microfluidics as A Tool to Understand the Build-Up Mechanism of Exponential-Like Growing Films
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DOI：
10.1002/marc.201200353
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发表时间：
2012-10-26
影响因子：
4.6
通讯作者：
Volodkin, Dmitry V.
中科院分区：
文献类型：
--
作者：
Madaboosi, Narayanan;Uhlig, Katja;Volodkin, Dmitry V.
微流体在这里首次用于有效地调整生长条件，以了解指数增长的聚乙烯（PE）薄膜的建立机制。在逐层组装过程中，可以成功地改变PE供应的速度和相互作用的时间。该方法的另一个优点是，可以通过荧光显微镜在线监测聚-L-赖氨酸/透明质酸（PLL/HA）膜在微通道中的沉积。研究表明，PE的质量传输到膜表面和在膜中的扩散是影响PLL/HA膜建立的关键参数。PE供应速率的增加导致朝向更高数量的沉积步骤的过渡（指数到线性增长）的变化，从而指示质量传输介导的增长机制。
Microfluidics is used here for the first time to efficiently tune the growth conditions for understanding the build-up mechanism of exponentially growing polyelectrolyte (PE) films. The velocity of PE supply and time of interaction can be successfully altered during the layer-by-layer assembly. Another advantage of this method is that the deposition of poly-L-lysine/hyaluronic acid (PLL/HA) films in microchannels can be monitored online by fluorescence microscopy. The study demonstrates that PE mass transport to the film surface and diffusion in the film are key parameters affecting PLL/HA film build-up. Increase of PE supply rate results in a change in the transition (exponential-to-linear growth) towards higher number of deposition steps, thus indicating a mass transport-mediated growth mechanism.