Serum uric acid and its relation to cardiovascular disease risk factors in children and young adults from a biracial community: the Bogalusa Heart Study.
Serum uric acid and its relation to cardiovascular disease risk factors in children and young adults from a biracial community: the Bogalusa Heart Study.
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DOI：
10.5555/uri:pii:002221439190068i
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发表时间：
1991-09
期刊：
影响因子：
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通讯作者：
E. Agamah;S. Srinivasan;L. Webber;G. Berenson
中科院分区：
文献类型：
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作者：
E. Agamah;S. Srinivasan;L. Webber;G. Berenson
对来自黑人和白人混血儿(黑人和白人)的3983名5-26岁的儿童和年轻人的血尿酸分布及其与心血管危险变量的关系进行了研究。在5~11岁和19~26岁两个年龄段，白人的尿酸水平显著高于黑人(分别为4.02 mg/dl vs3.57 mg/dl，p<0.0001；5.5 mg/dl vs5.18 mg/dl，p<0.0001)。19~26岁年龄组男性尿酸水平显著高于女性(6.49 mg/dl比4.20 mg/dl，p<0.0001)。白人儿童和年轻人的尿酸水平高于黑人的可能性是黑人的两倍，男性高尿酸血症的可能性比女性更高。有心肌梗塞病史的父母更有可能生下高尿酸血症的孩子。儿童和青壮年高尿酸血症患者的血糖(p<0.001)、胰岛素(p<0.001)、总胆固醇(p<0.05)、甘油三酯(p<0.0001)、极低密度脂蛋白胆固醇(p<0.01)、低密度脂蛋白胆固醇(p<0.001)和总蛋白(p<0.0001)水平显著高于非高尿酸血症患者；高尿酸血症患者的高密度脂蛋白胆固醇水平显著低于非高尿酸血症患者(p<0.0001)。
The distribution of serum uric acid and its relationship with cardiovascular risk variables have been studied in 3983 children and young adults, aged 5 to 26 years, drawn from a biracial (black and white) population. For two age groups, 5 to 11 years and 19 to 26 years, white subjects had significantly higher uric acid levels than black subjects, (4.02 mg/dl vs 3.57 mg/dl, p less than 0.0001, and 5.50 mg/dl vs 5.18 mg/dl, p less than 0.0001, respectively). Men in the 19 to 26 years age group had a significantly higher uric acid level than women (6.49 mg/dl vs 4.20 mg/dl, p less than 0.0001). White children and young adults were twice as likely to have levels above clinical limits than blacks, and males more likely to have hyperuricemia than females. Parents with a history of myocardial infarction were more likely to have children with hyperuricemia. Children and young adults with hyperuricemia had significantly higher plasma glucose (p less than 0.01) and insulin (p less than 0.001) levels, total cholesterol level (p less than 0.05), and serum triglyceride (p less than 0.0001), very-low-density lipoprotein cholesterol (p less than 0.01), low-density lipoprotein cholesterol (p less than 0.001), and total protein (p less than 0.0001) levels than subjects without hyperuricemia; high-density lipoprotein cholesterol level was significantly lower (p less than 0.0001) in subjects with hyperuricemia than in those without it.(ABSTRACT TRUNCATED AT 250 WORDS)