Epidemiological evidence for a hereditary contribution to myasthenia gravis: a retrospective cohort study of patients from North America.
Epidemiological evidence for a hereditary contribution to myasthenia gravis: a retrospective cohort study of patients from North America.
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DOI：
10.1136/bmjopen-2020-037909
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发表时间：
2020-09-18
期刊：
影响因子：
2.9
通讯作者：
Traynor BJ
中科院分区：
文献类型：
--
作者：
Green JD;Barohn RJ;Bartoccion E;Benatar M;Blackmore D;Chaudhry V;Chopra M;Corse A;Dimachkie MM;Evoli A;Florence J;Freimer M;Howard JF;Jiwa T;Kaminski HJ;Kissel JT;Koopman WJ;Lipscomb B;Maestri M;Marino M;Massey JM;McVey A;Mezei MM;Muppidi S;Nicolle MW;Oger J;Pascuzzi RM;Pasnoor M;Pestronk A;Provenzano C;Ricciardi R;Richman DP;Rowin J;Sanders DB;Siddiqi Z;Soloway A;Wolfe GI;Wulf C;Drachman DB;Traynor BJ
To approximate the rate of familial myasthenia gravis and the coexistence of other autoimmune disorders in the patients and their families. Retrospective cohort study. Clinics across North America. The study included 1032 patients diagnosed with acetylcholine receptor antibody (AChR)-positive myasthenia gravis. Phenotype information of 1032 patients diagnosed with AChR-positive myasthenia gravis was obtained from clinics at 14 centres across North America between January 2010 and January 2011. A critical review of the epidemiological literature on the familial rate of myasthenia gravis was also performed. Among 1032 patients, 58 (5.6%) reported a family history of myasthenia gravis. A history of autoimmune diseases was present in 26.6% of patients and in 28.4% of their family members. The familial rate of myasthenia gravis was higher than would be expected for a sporadic disease. Furthermore, a high proportion of patients had a personal or family history of autoimmune disease. Taken together, these findings suggest a genetic contribution to the pathogenesis of myasthenia gravis.
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影响因子：
29
作者：
Renton AE;Pliner HA;Provenzano C;Evoli A;Ricciardi R;Nalls MA;Marangi G;Abramzon Y;Arepalli S;Chong S;Hernandez DG;Johnson JO;Bartoccioni E;Scuderi F;Maestri M;Gibbs JR;Errichiello E;Chiò A;Restagno G;Sabatelli M;Macek M;Scholz SW;Corse A;Chaudhry V;Benatar M;Barohn RJ;McVey A;Pasnoor M;Dimachkie MM;Rowin J;Kissel J;Freimer M;Kaminski HJ;Sanders DB;Lipscomb B;Massey JM;Chopra M;Howard JF Jr;Koopman WJ;Nicolle MW;Pascuzzi RM;Pestronk A;Wulf C;Florence J;Blackmore D;Soloway A;Siddiqi Z;Muppidi S;Wolfe G;Richman D;Mezei MM;Jiwa T;Oger J;Drachman DB;Traynor BJ
通讯作者：
Traynor BJ
影响因子：
82.9
作者：
Hoch, W;McConville, J;Vincent, A
通讯作者：
Vincent, A
影响因子：
14.5
作者：
MacDonald, BK;Cockerell, OC;Shorvon, SD
通讯作者：
Shorvon, SD
影响因子：
4.4
作者：
Murai, Hiroyuki;Yamashita, Natsumi;Kira, Jun-ichi
通讯作者：
Kira, Jun-ichi
DOI：
10.1196/annals.1405.027
发表时间：
2008-01-01
期刊：
MYASTHENIA GRAVIS AND RELATED DISORDERS: 11TH INTERNATIONAL CONFERENCE
影响因子：
--
作者：
Giraud, Matthieu;Vandiedonck, Claire;Garchon, Henri Jean
通讯作者：
Garchon, Henri Jean