Reigoselective arylation of thiazole derivatives at 5-position via Pd catalysis under ligand-free conditions.
Reigoselective arylation of thiazole derivatives at 5-position via Pd catalysis under ligand-free conditions.
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DOI：
10.1021/ol4027073
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发表时间：
2013-10
期刊：
影响因子：
5.2
通讯作者：
Xiangrong Liu;Jiang-Ling Shi;Jia-Xuan Yan;Jiangbo Wei;Kun Peng;L. Dai;Chen-Guang Li;Bi-qin Wang;Zhangjie Shi
中科院分区：
文献类型：
--
作者：
Xiangrong Liu;Jiang-Ling Shi;Jia-Xuan Yan;Jiangbo Wei;Kun Peng;L. Dai;Chen-Guang Li;Bi-qin Wang;Zhangjie Shi
报道了一种通过pd催化的C-H活化的高效区域选择性芳基化噻唑衍生物。在没有特殊配体的情况下，假设通过Pd（0/II）催化循环进行转化。该方法为噻唑5位直接芳基化提供了一种有效的方法。
An efficient regioselective arylation of thiazole derivatives via Pd-catalyzed C-H activation is reported. The transformation was hypothesized through a Pd(0/II) catalytic cycle in the absence of special ligand sets. This method provided an efficient process to direct arylation of thiazoles at the 5-position.