Triterpenoids from stems of Kadsura heteroclita
Triterpenoids from stems of Kadsura heteroclita
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DOI：
10.1016/j.fitote.2019.104441
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发表时间：
2020-01-01
期刊：
影响因子：
3.4
通讯作者：
Wang, Wei
中科院分区：
文献类型：
--
作者：
Cao, Liang;Li, Bin;Wang, Wei
本文报道了从土家族药用植物海风藤正丁醇提取物中分离得到的三萜类化合物。分离得到6个未见文献报道的三萜化合物血通素A-F(1-6)和5个已知的三萜化合物(7-11)。化合物的结构经一维、二维核磁共振和HRESIMS谱确证，并结合圆二色谱进行分析。通过X-射线衍射法测定了化合物7的绝对立体化学结构。化合物7对HL-60表现出较弱的细胞毒活性，IC50值为50.0mM。
In the present work, we reported the triterpenoids isolated from n-butanol fraction of Kadsura heteroclita which is a Tujia ethnomedicine with trivial name "Xuetong". This effort resulted in the isolation of six unpresented triterpenoids xuetongsu A-F (1-6), along with five known triterpenoids (7-11). The structures of the reported compounds were established on the 1D, and 2D NMR and HRESIMS spectra, along with CD spectroscopic analysis. Moreover, the absolute stereochemistry of compound 7 was determined by X-ray diffraction analysis. Antioxidant and cytotoxic activities were evaluated for all isolated compounds, compound 7 shown weak cytotoxic activity against HL-60 with IC50 value of 50.0 mu M.