Prognostic significance of the progesterone receptor status in Ki67-high and -low Luminal B-like HER2-negative breast cancers
Prognostic significance of the progesterone receptor status in Ki67-high and -low Luminal B-like HER2-negative breast cancers
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DOI：
10.1007/s12282-014-0575-6
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发表时间：
2016-03-01
期刊：
影响因子：
4
通讯作者：
Ohuchi, Noriaki
中科院分区：
文献类型：
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作者：
Sato, Kaolu;Miyashita, Minoru;Ohuchi, Noriaki
乳腺癌是一种异质性疾病，免疫组织化学评价是一种替代标记物，广泛用于临床环境中，以确定内在亚型。在2013年圣加仑会议上改变了管腔B样乳腺癌的定义;因此，我们研究了最新定义中分类的新管腔B样乳腺癌的临床病理学特征。我们还比较了传统的PgR高管腔B样乳腺癌与传统的PgR低或阴性管腔B样乳腺癌。我们调查了2005-2008年在一个单一的机构手术的118例管腔HER 2阴性乳腺癌患者。检索每例患者的病史数据。一个患者子集（14.4%）由于PgR低或阴性而被归类为新的管腔B样：58.8%为组织学I级，65%为肿瘤大小T1，一半有淋巴结受累。一半的病例进行了化疗。新发Luminal B样乳腺癌的乳腺癌相关事件发生率高于Luminal A样乳腺癌，低于传统Luminal B样乳腺癌。多因素分析显示，PgR低表达或阴性表达及未接受激素治疗是预后不良的因素。当根据PgR状态分为两组时，48.1%的传统管腔B样乳腺癌为PgR高;该组中肿瘤尺寸较小，淋巴结受累较少。常规PgR高的Luminal B样乳腺癌的辅助化疗率低于常规PgR低或阴性的Luminal B样乳腺癌。在传统的PgR高的Luminal B样乳腺癌中，乳腺癌相关事件显着降低。我们的结果表明PgR状态可能对Luminal HER 2阴性乳腺癌的预后有一定影响。因此，应注意PgR状态以及Ki-67。
Breast cancer is a heterogeneous disease, and immunohistochemical evaluation is a surrogate marker that is widely used in clinical settings to identify the intrinsic subtypes. The definition of the Luminal B-like breast cancer was changed at the 2013 St. Gallen meeting; therefore, we investigated the clinicopathological features of the new Luminal B-like breast cancer categorized in the latest definition. We also compared the conventional PgR-high Luminal B-like breast cancer with the conventional PgR-low or -negative Luminal B-like breast cancer.We investigated 118 Luminal HER2-negative breast cancer patients who were operated in 2005-2008 at a single institution. Data on each patient's medical history were retrieved.A subset of patients (14.4 %) was categorized as the new Luminal B-like due to low or negative PgR: 58.8 % were histological grade I, 65 % were T1 in tumor size, and half had node involvement. Chemotherapy was performed in half of the cases. Breast cancer-related events were more frequent for the new Luminal B-like breast cancer than for the Luminal A-like breast cancer and were less frequent than for the conventional Luminal B-like breast cancer. Based on multivariate analysis, low or negative expression of PgR and the absence of hormonal therapy were worse prognostic factors. When categorized into two groups by the PgR status, 48.1 % of the conventional Luminal B-like breast cancer was PgR-high; tumor size was smaller, and nodal involvement was less in this group. The rate of adjuvant chemotherapy of the conventional PgR-high Luminal B-like breast cancer was less than that of the conventional PgR-low or -negative Luminal B-like breast cancer. Breast cancer-related events were significantly lower in the conventional PgR-high Luminal B-like breast cancer.Our results show the possibility that PgR status has some influence on the prognosis for Luminal HER2-negative breast cancers. Therefore, attention should be paid to the PgR status as well as Ki-67.