Barriers to Obtaining Sera and Tissue Specimens of African-American Women for the Advancement of Cancer Research.
Barriers to Obtaining Sera and Tissue Specimens of African-American Women for the Advancement of Cancer Research.
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DOI：
10.4137/cmwh.s34698
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Denis GV
中科院分区：
文献类型：
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作者：
Strissel KJ;Nicholas DA;Castagne-Charlotin M;Ko N;Denis GV
非洲裔美国女性是一个历史上研究不足、服务不足的群体，她们患三阴性乳腺癌和肥胖相关疾病的风险增加。肥胖相关的代谢性疾病共有一个共同的联系，即低级别的慢性炎症，但并不是所有的肥胖女性都有代谢障碍或发炎。我们正在进行的研究的一个目标是确定可以预测肥胖或代谢障碍女性乳腺癌风险增加的血液生物标志物。然而，从生物医学研究的进步中获益最多的弱势群体在研究研究中也没有得到充分的代表。开发有效的、新的癌症预防和治疗方法将需要大量的基础医学研究工作，以在多个人群中建立必要的证据基础。在一家安全网医院与脆弱的人类受试者一起工作，使我们能够对从非裔美国妇女那里获得血清学和组织标本的潜在障碍发表评论。在这里，我们报告了参与我们正在进行的研究的一些意想不到的障碍，这些障碍可能会为未来的努力提供参考。
African-American women, a historically understudied and underserved group, have increased risk for triple-negative breast cancer and obesity-associated disease. Obesity-associated metabolic diseases share a common link of low grade chronic inflammation, but not all obese women have metabolic disturbances or are inflamed. One goal of our ongoing research is to identify blood biomarkers that can predict increased risk of breast cancer in women who have obesity or metabolic dysfunction. However, vulnerable populations that stand to benefit most from advances in biomedical research are also underrepresented in research studies. The development of effective, novel approaches for cancer prevention and treatment will require significant basic medical research effort to establish the necessary evidence base in multiple populations. Work with vulnerable human subjects at a safety net hospital enabled us to comment on potential obstacles to obtaining serological and tissue specimens from African-American women. Here, we report some unexpected barriers to participation in our ongoing research study that might inform future efforts.