Polyamidoamine Starburst® dendrimers as solubility enhancers
Polyamidoamine Starburst® dendrimers as solubility enhancers
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DOI：
10.1016/s0378-5173(99)00463-9
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发表时间：
2000-03-20
影响因子：
5.8
通讯作者：
D'Emanuele, A
中科院分区：
文献类型：
--
作者：
Milhem, OM;Myles, C;D'Emanuele, A
比较了疏水性药物布洛芬在聚酰胺胺（PAMAM）G4树枝状聚合物和十二烷基硫酸钠（SDS）水溶液中的溶解度。与2%SDS溶液相比，PAMAM G4树枝状聚合物溶液显著提高了布洛芬的溶解度。发现布洛芬在树枝状大分子溶液中的溶解度与树枝状大分子浓度成正比，与温度成反比。树枝状聚合物溶液的pH值对布洛芬的溶解度增强的影响表明，它涉及布洛芬分子的羧基和树枝状聚合物分子的胺基之间的静电相互作用。(C)2000 Elsevier Science B.V.保留所有权利。
The solubility of the hydrophobic drug ibuprofen has been compared in an aqueous solution of polyamidoamine (PAMAM) G4 dendrimer and sodium dodecyl sulphate (SDS). The PAMAM G4 dendrimer solution significantly enhanced the solubility of ibuprofen compared to 2% SDS solution. It was found that the solubility of ibuprofen in dendrimer solution was directly proportional to dendrimer concentration and inversely proportional to temperature. The influence of dendrimer solution pH on the solubility enhancement of ibuprofen suggests that it involves an electrostatic interaction between the carboxyl group of the ibuprofen molecule and the amine groups of the dendrimer molecule. (C) 2000 Elsevier Science B.V. All rights reserved.