Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery
Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery
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DOI：
10.1016/j.cyto.2013.11.009
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发表时间：
2014-02-01
期刊：
影响因子：
3.8
通讯作者：
Fasshauer, Mathias
中科院分区：
文献类型：
--
作者：
Ebert, Thomas;Stepan, Holger;Fasshauer, Mathias
目的：淫羊藿素是一种新型的运动诱导型肌动蛋白，可改善小鼠的糖代谢。然而，到目前为止，对妊娠期糖尿病(GDM)和围产期循环虹膜蛋白的调节作用还没有得到评估。方法：对74例GDM患者和74例健康、妊娠、胎龄匹配的对照组进行循环虹膜蛋白定量。在这些患者中的一部分(44名妊娠期糖尿病患者，41名对照)，产后随访数据也可用。结果：在第二个研究人群中，妊娠期糖尿病患者产后[四分位数范围]的中位数显著高于对照组(既往妊娠期糖尿病：446.3[146.9]mU/L；对照组：378.0[111.4]mU/L)，但在妊娠期(妊娠期：482.1[132.1]mU/L；对照：466.6[178.0]亩/L)。有趣的是，在孕期多因素分析中，空腹胰岛素(FI)与血清淫羊藿素独立且正相关。与这些发现一致的是，在第二个研究人群中，FI的相对变化(比率)独立地正向预测虹膜蛋白(比率)的相对变化。结论：肌动因子虹膜蛋白与妊娠FI独立相关。这些发现的生理意义需要在未来的实验中进行评估。(C)2013爱思唯尔有限公司。保留所有权利。
Objective: Irisin has recently been introduced as a novel an exercise-inducible myokine which improves glucose metabolism in mice. However, regulation of circulating irisin in gestational diabetes mellitus (GDM) and in the peripartal period has not been assessed so far.Methods: Circulating irisin was quantified in 74 GDM patients and in 74 healthy, pregnant, gestational age-matched controls. In a subset of these patients (44 GDM, 41 controls), postpartum follow-up data were also available. In a second study population of 40 healthy women with singleton pregnancies undergoing elective Cesarean section, irisin was assessed in maternal serum before and within 24 h after delivery, as well as in umbilical cord blood and in placental tissue.Results: In the first study population, median [interquartile range] irisin levels were significantly higher in GDM patients as compared to controls after delivery (previous GDM: 446.3 [146.9] mu g/l; controls: 378.0 [111.4] mu g/l) but not during pregnancy (GDM: 482.1 [132.1] mu g/l; controls: 466.6 [178.0] mu g/l). Interestingly, fasting insulin (FI) was independently and positively associated with serum irisin in multivariate analysis during pregnancy. In agreement with these findings, relative changes (ratio) of FI independently and positively predicted relative changes of irisin (ratio) in the second study population.Conclusions: The myokine irisin is independently associated with FI in pregnancy. The physiological significance of these findings needs to be assessed in future experiments. (C) 2013 Elsevier Ltd. All rights reserved.