Fully Implanted Brain-Computer Interface in a Locked-In Patient with ALS.
Fully Implanted Brain-Computer Interface in a Locked-In Patient with ALS.
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DOI：
10.1056/nejmoa1608085
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发表时间：
2016-11-24
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影响因子：
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通讯作者：
Ramsey NF
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作者：
Vansteensel MJ;Pels EGM;Bleichner MG;Branco MP;Denison T;Freudenburg ZV;Gosselaar P;Leinders S;Ottens TH;Van Den Boom MA;Van Rijen PC;Aarnoutse EJ;Ramsey NF
严重瘫痪的人失去了口头交流的能力，他们的选择是有限的。我们描述了一种用于晚期肌萎缩侧索硬化症（ALS）患者的通信方法，涉及完全植入的脑机接口，该接口由放置在运动皮层上的硬膜下电极和放置在胸部左侧皮下的发射器组成。通过尝试在植入电极的对面移动手，患者在电极放置后28周准确且独立地控制计算机打字程序，相当于每分钟两个字母。脑机接口提供自主通信，补充并有时取代患者的眼球跟踪设备。（由荷兰政府和欧洲联盟供资; ClinicalTrials.gov编号，NCT 02224469。
Options for people with severe paralysis who have lost the ability to communicate orally are limited. We describe a method for communication in a patient with late-stage amyotrophic lateral sclerosis (ALS), involving a fully implanted brain–computer interface that consists of subdural electrodes placed over the motor cortex and a transmitter placed subcutaneously in the left side of the thorax. By attempting to move the hand on the side opposite the implanted electrodes, the patient accurately and independently controlled a computer typing program 28 weeks after electrode placement, at the equivalent of two letters per minute. The brain–computer interface offered autonomous communication that supplemented and at times supplanted the patient’s eye-tracking device. (Funded by the Government of the Netherlands and the European Union; ClinicalTrials.gov number, NCT02224469.)