Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus
Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus
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DOI：
10.1128/jvi.02582-15
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发表时间：
2016-03-01
影响因子：
5.4
通讯作者：
Shi, Zheng-Li
中科院分区：
文献类型：
--
作者：
Yang, Xing-Lou;Hu, Ben;Shi, Zheng-Li
我们报告了一种新的蝙蝠冠状病毒的分离和鉴定，它在基因组序列上比以前报道的其他人更接近严重急性呼吸综合征冠状病毒（SARS-CoV），特别是在其S基因上。细胞进入和敏感性研究表明，该病毒可以使用ACE 2作为受体并感染动物和人类细胞系。我们的研究结果为SARS-CoV的蝙蝠起源提供了进一步的证据，并强调了未来蝙蝠冠状病毒在人类中出现的可能性。
We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.