Evidence for genetic associations between asthma, atopy, and bronchial hyperresponsiveness - A study of 8-to 18-yr-old twins
Evidence for genetic associations between asthma, atopy, and bronchial hyperresponsiveness - A study of 8-to 18-yr-old twins
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DOI：
10.1164/ajrccm.162.6.9904057
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发表时间：
2000-12-01
影响因子：
24.7
通讯作者：
Robertson, CF
中科院分区：
文献类型：
--
作者：
Clarke, JR;Jenkins, MA;Robertson, CF
我们从澳大利亚双胞胎登记处挑选了381名8至18岁的双胞胎疼痛患者，测量了过去12个月内由呼吸科医生在访谈中诊断出的哮喘；特应性，通过对八种常见过敏原中的任何一种的皮肤点刺试验呈阳性定义；以及对高渗盐水的支气管高反应性(BHR)。双胞胎之间的关联，通过优势比测量，在哮喘方面，MZ对比DZ对更大：25.6(95%可信区间11.3-57.8)对1.9(1.0-3.5)；特应性：14.6(7.1-30.1)对25(1.4-4.5)；BHR：14.1(6.4-31.0)对4.2(2.1-8.6)(均P<；0.002)。在MZ配对中，个体内每对性状之间的关联略大于双胞胎(交叉性状交叉配对)中双胞胎中的一个性状和另一个性状之间的关联。此外，MZ配对的关联性大于DZ配对(p<；0.05)。在经典双胞胎模型的假设下，这些数据表明，这三个性状之间的强烈横截面关联是由于这三个性状中每一个所涉及的遗传因素之间的重叠。
We measured asthma in the last 12 mo, diagnosed by a respiratory physician at interview; atopy, defined by a positive skin prick test to any of eight common allergens; and bronchial hyperresponsiveness (BHR) to hypertonic saline, in 381 twin pain aged 8 to 18 yr selected from the Australian Twin Registry-183 monozygous (MZ) and 198 dizygous (DZ). The associations between twins, as measured by an odds ratio, were greater in MZ pairs compared with DZ pairs for asthma: 25.6 (95% confidence interval 11.3-57.8) versus 1.9 (1.0-3.5); atopy: 14.6 (7.1-30.1) versus 25 (1.4-4.5); and BHR: 14.1 (6.4-31.0) versus 4.2 (2.1-8.6) (all p < 0.002). The associations between each pair of traits within an individual were slightly greater than the association between one trait in a twin and the other trait in the cotwin (cross-trait cross-pair) in MZ pairs. Further, the associations in MZ pairs were greater than in DZ pairs (p < 0.05). Under the assumptions of the classic twin model, these data suggest that the strong cross-sectional associations between these three traits are due to an overlap between the genetic factors involved in each of these three traits.