Radiotelemetered cystometry in pigs: Validation and comparison of natural filling versus diuresis cystometry
Radiotelemetered cystometry in pigs: Validation and comparison of natural filling versus diuresis cystometry
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DOI：
10.1016/s0022-5347(05)67100-5
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发表时间：
2000-11-01
影响因子：
6.6
通讯作者：
Brading, AF
中科院分区：
文献类型：
--
作者：
Mills, IW;Noble, JG;Brading, AF
目的：以前曾使用膀胱和腹部导管以及人工膀胱充盈在清醒的动物中进行膀胱测量。尽管是在非生理和潜在压力条件下，仍可以以这种方式获得常规尿动力学记录。因此，我们开发了一种对猪进行连续、动态膀胱测压监测的技术。材料和方法：通过手术将双压力无线电遥测装置植入 22 头大白猪体内。记录并验证膀胱和腹部压力，导出逼尿肌压力，比较自然充盈和利尿膀胱测压。结果：获得 1 至 24 小时的连续记录，装置在动物体内保留长达 3 个月。很少出现并发症，膀胱内导管尖端结垢，但似乎不会影响记录的压力。通过与膀胱扩张期间的充盈压力和实验结束时同时进行的常规膀胱测压进行比较来验证压力数据。自然充盈和利尿膀胱测压图的比较表明，自然充盈的膀胱会导致排尿期间较高的最大逼尿肌压力（38.1 与 33.9 cm. H2O，p
Purpose: Cystometry has previously been performed in awake animals using vesical and abdominal catheters, and artificial bladder filling. Conventional urodynamic recordings may be obtained in this manner, albeit under nonphysiological and potentially stressful conditions. Therefore, we developed a technique to perform continuous, ambulatory cystometric monitoring in pigs.Materials and Methods: A dual pressure radiotelemetry device was surgically implanted in 22 large white pigs. Vesical and abdominal pressures were recorded and validated, subtracted detrusor pressures were derived and natural fill and diuresis cystometry was compared.Results: Continuous recordings were obtained for 1 to 24 hours, and the devices remained in the animals for up to 3 months. There were few complications and incrustation of the intravesical catheter tip occurred but it did not appear to affect recorded pressures. The pressure data were validated by comparison with filling pressures during bladder distention and simultaneous conventional cystometry at the end of the experimental period. Comparison of natural filling and diuresis cystometrograms showed that natural bladder filling results in higher maximum detrusor pressure during voiding (38.1 versus 33.9 cm. H2O, p