MicroRNA-139 targets fibronectin 1 to inhibit papillary thyroid carcinoma progression.
MicroRNA-139 targets fibronectin 1 to inhibit papillary thyroid carcinoma progression.
复制标题
MicroRNA-139 靶向纤连蛋白 1 抑制甲状腺乳头状癌进展
DOI：
10.3892/ol.2017.7201
复制
发表时间：
2017-12
期刊：
影响因子：
2.9
通讯作者：
Xia W
中科院分区：
文献类型：
--
作者：
Ye Y;Zhuang J;Wang G;He S;Ni J;Xia W
甲状腺癌是内分泌系统最常见的肿瘤，其发病率在过去几十年中显著增加。据报道，异常表达的微小RNA（miRNAs）通过调节其靶基因参与甲状腺乳头状癌（PTC）的形成和进展。因此，miRNAs有可能成为PTC预测和预后的潜在分子生物标志物，也可能成为PTC治疗的新靶点。miR-139最近被报道在几种类型的癌症中异常表达。然而，miR-139在PTC中的表达水平、生物学功能及其相关的分子机制尚不清楚。本研究的结果显示，miR-139的表达在PTC组织和细胞系中下调时，分别与相邻的正常组织和正常人甲状腺细胞相比。miR-139表达的恢复抑制了体外PTC中细胞的增殖和侵袭。此外，纤连蛋白1（FN 1）被确定为PTC中miR-139的直接靶点。FN 1在PTC组织中高表达，与miR-139表达呈负相关。此外，miR-139过表达对PTC细胞的肿瘤抑制作用通过异位FN 1表达而改善。据我们所知，本研究首次证明miR-139可能作为肿瘤抑制因子，并通过靶向PTC细胞中的FN 1在抑制肿瘤发生中发挥重要作用。
Thyroid cancer is the most common tumour of the endocrine system, and its incidence rate has markedly increased over the past several decades. Aberrantly expressed microRNAs (miRNAs) are reportedly involved in the formation and progression of papillary thyroid carcinoma (PTC) by regulating their target genes. Thus, miRNAs may be potential molecular biomarkers for the prediction and prognosis of PTC, and also as novel therapeutic targets for patients with PTC. miR-139 has recently been reported to be aberrantly expressed in several types of cancer. However, the expression levels, biological functions and the associated molecular mechanism of miR-139 in PTC have not been clearly elucidated. The results of the present study revealed that miR-139 expression was downregulated in PTC tissues and cell lines when compared with adjacent normal tissues and normal human thyroid cells, respectively. The restoration of miR-139 expression suppressed cellular proliferation and invasion in PTC in vitro. In addition, fibronectin 1 (FN1) was identified as a direct target of miR-139 in PTC. Furthermore, FN1 was highly expressed in PTC tissues and negatively associated with miR-139 expression. Moreover, the tumour-suppressive effects of miR-139 overexpression on PTC cells were ameliorated by ectopic FN1 expression. To the best of our knowledge, the present study is the first to demonstrate that miR-139 may serve as a tumour suppressor and serve important roles in inhibiting tumourigenesis by targeting FN1 in PTC cells.
登录
查看更多内容
miR-139对RAP1B的调节抑制人结直肠癌细胞增殖
DOI：
10.1016/j.biocel.2012.05.015
发表时间：
2012-09-01
影响因子：
4
作者：
Guo, Haiyan;Hu, Xiaobo;Zhang, Jianjun
通讯作者：
Zhang, Jianjun
影响因子：
8
作者：
通讯作者：
--
影响因子：
3.6
作者：
Jerhammar, Fredrik;Ceder, Rebecca;Roberg, Karin
通讯作者：
Roberg, Karin
影响因子：
11.2
作者：
Jones KB;Salah Z;Del Mare S;Galasso M;Gaudio E;Nuovo GJ;Lovat F;LeBlanc K;Palatini J;Randall RL;Volinia S;Stein GS;Croce CM;Lian JB;Aqeilan RI
通讯作者：
Aqeilan RI
影响因子：
13.2
作者：
Baydar, Dilek Ertoy;Kutlugun, Aysun Aybal;Piras, Rossella
通讯作者：
Piras, Rossella