Significance of recanalization of sinuses and resolution of parenchymal lesion in cerebral venous sinus thrombosis
Significance of recanalization of sinuses and resolution of parenchymal lesion in cerebral venous sinus thrombosis
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DOI：
10.1016/j.jocn.2020.04.112
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发表时间：
2020-07-01
影响因子：
2
通讯作者：
Kumar, Sunil
中科院分区：
文献类型：
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作者：
Singh, Varun K.;Jain, Neeraj;Kumar, Sunil
在脑静脉窦血栓形成(CVST)中，血管再通的程度可能决定实质病变的消退和临床预后。本研究的目的是评估血管再通与MRI病变分辨率和临床结果的关系。前瞻性纳入经磁共振静脉成像(MRV)诊断的CVST患者。记录危险因素、临床特征、MRI和MRV表现。术后6个月复查MRI和MRV，记录病变实质和血管再通程度(I、II、III级)的变化。在3个月和6个月时对患者进行临床评估。以改良Rankin评分(MRS)为0分为完全恢复组，纳入33例CVST患者，其中女性12例(36.4%)。再通29例(87.9%)，完全再通(III级)6例(21%)。乙状窦再通频率较高(52%)。13.3%(4/30)的患者在复查MRI上病灶消退，无后遗症。再通程度与神经后遗症的缓解、随访时的MRI损害及基线血栓负荷无关，87.9%的CVST患者有不同程度的再通，13.3%的患者实质病变消失。然而，临床结果与血管再通无关。(C)2020爱思唯尔有限公司。保留所有权利。
In cerebral venous sinus thrombosis (CVST), the degree of recanalization may determine resolution of parenchymal lesion and clinical outcome. The aim of our study was to evaluate the relationship of recanalization with resolution of MRI lesion and clinical outcome.The patients with CVST diagnosed on the basis of magnetic resonance venography (MRV) were included prospectively. Risk factors, clinical features, and MRI and MRV findings were noted. MRI and MRV were repeated at 6 months and the change in parenchymal lesion and grade of recanalization (I, II, III) were noted. Patients were evaluated clinically at three and six months. Complete recovery was considered if modified Rankin Scale (mRS) score was 0.Thirty-three CVST patients were included, 12 (36.4%) of whom were females. Recanalization occurred in 29 (87.9%), which was complete (grade III) in 6 (21%). Sigmoid sinus (52%) recanalized more frequently. Resolution of parenchymal lesion on repeat MRI occurred in 13.3% (4/30) patients, and they had no sequelae. Degree of recanalization was not related to resolution of neurological sequelae, MRI lesion at follow up and burden of thrombosis at baseline.Varying degree of recanalization occurred in 87.9% patients with CVST, and resolution of parenchymal lesion occurred in 13.3%. Clinical outcome however was not related to recanalization. (C) 2020 Elsevier Ltd. All rights reserved.