Total femoral reconstruction with custom prosthesis for osteosarcoma.
Total femoral reconstruction with custom prosthesis for osteosarcoma.
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DOI：
10.1186/s12957-016-0852-2
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发表时间：
2016-03-31
影响因子：
3.2
通讯作者：
Guo X
中科院分区：
文献类型：
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作者：
Liu T;Zhang X;Zhang Q;Zhang X;Guo X
本研究的目的是评估全股骨置换术治疗股骨骨肉瘤的效果。1995年1月至2012年1月，共有21例患者接受股骨骨肉瘤全股骨置换术治疗，平均年龄21.8岁。所有肿瘤均按Enneking标准分期，IIA期1例，IIB期20例。无转移骨肉瘤患者5年生存率为66.7%。12例患者存活，总平均随访时间为71.2个月，最后一次随访时平均术后功能评分为72.5%。2例患者发生浅表感染，经换药及静脉注射抗生素解决。1例患者发生深部感染，为髋关节脱臼截肢。髌骨骨折1例，经切开复位张力带固定治疗。局部复发在一个病人，这是一个截肢髋关节脱臼。9例患者出现肺转移，所有患者随后在12个月内死亡。3例患者发生胫骨干无菌性松动，全假体修复。全股骨置换术是广泛切除股骨后恢复机械和功能效果的可靠方法。
The aim of this study was to assess total femur replacement for the treatment of femoral osteosarcomas. Between January 1995 and January 2012, 21 patients with a mean age of 21.8 years old were treated for femoral osteosarcomas with total femur replacement. All tumors were staged according to Enneking’s criteria with one stage IIA case and 20 stage IIB cases. The survival of patients with osteosarcoma without metastases was 66.7 % at 5 years. Twelve patients were alive with an overall mean follow-up of 71.2 months, and the mean postoperative functional score was 72.5 % at their last follow-up. Superficial infection occurred in two patients, which were resolved by changing dressing and intravenous antibiotics. Deep infection occurred in one patient, which was an amputation by hip disarticulation. Patella fracture occurred in one patient, which was treated by open reduction and tension band fixation. Local recurrence was seen in one patient, which was an amputation by hip disarticulation. Pulmonary metastases were observed in nine patients and all the patients subsequently died of disease within 12 months. Aseptic loosening in tibial stem occurred in three patients, whose whole prosthesis was revised. Total femur replacement is a reliable method to restore mechanical and functional results after extensive resection of the femur.