Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration
Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration
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DOI：
10.1016/s0955-0674(97)80126-3
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发表时间：
1997-10-01
影响因子：
7.5
通讯作者：
Chapman, HA
中科院分区：
文献类型：
--
作者：
Chapman, HA
细胞迁移严重依赖于附着力和分离力之间的相互作用。最近的研究表明，丝氨酸蛋白酶尿激酶及其主要抑制剂和受体至少在一定程度上通过启动细胞信号来调节整合素的粘附特性。旧蛋白酶系统的这些新功能意味着在细胞表面调节迁移的蛋白水解和粘附之间存在复杂的联系。
Cellular migration is critically dependent on an interplay between forces of attachment and detachment. Recent studies show that the serine protease urokinase and its major inhibitor and receptor regulate the adhesive properties of integrins, at least in part through initiation of cellular signals. These new functions for an old protease system imply intricate connections between proteolysis and adhesion that operate at the cell surface to regulate migration.