Standardized antibacterial honey (Medihoney) with standard therapy in wound care: randomized clinical trial.
Standardized antibacterial honey (Medihoney) with standard therapy in wound care: randomized clinical trial.
复制标题
标准化抗菌蜂蜜（Medihoney）与伤口护理标准疗法：随机临床试验。
DOI：
10.1111/j.1365-2648.2008.04923.x
复制
发表时间：
2009
影响因子：
3.8
通讯作者：
Stephen Thomas
中科院分区：
文献类型：
--
作者：
V. Robson;S. Dodd;Stephen Thomas
目的
本文是一项研究报告，旨在比较医用级蜂蜜与常规治疗对二期愈合伤口愈合率的影响。
背景
越来越多的证据支持使用蜂蜜治疗伤口，但缺乏可靠的随机试验供临床医生作为临床判断的依据。
方法
105名患者参与了一项单中心、开放标签的随机对照试验，患者接受常规伤口敷料或蜂蜜治疗。数据收集时间为2004年9月至2007年5月。
结果
蜂蜜组愈合的中位时间为100天，而对照组为140天。12周时蜂蜜组的愈合率为46.2%，常规组为34.0%，两组12周时愈合率的差异（95%置信区间，CI）为12.2%（-13.6%，37.9%）。Cox回归得出的未经调整的风险比（95% CI）为1.30（0.77，2.19），P = 0.321。当针对混杂因素（性别、伤口类型、年龄和治疗开始时的伤口面积）调整治疗效果时，风险比增加到1.51，但同样无统计学意义。
结论
治疗开始时的伤口面积和性别都是对愈合时间具有高度统计学意义的预测因素。这些结果支持在伤口护理中使用蜂蜜具有临床益处这一观点，但还需要进一步研究。
AIM
This paper is a report of a study to compare a medical grade honey with conventional treatments on the healing rates of wounds healing by secondary intention.
BACKGROUND
There is an increasing body of evidence to support the use of honey to treat wounds, but there is a lack of robust randomized trials on which clinicians can base their clinical judgement.
METHOD
A sample of 105 patients were involved in a single centre, open-label randomized controlled trial in which patients received either a conventional wound dressing or honey. Data were collected between September 2004 and May 2007.
RESULTS
The median time to healing in the honey group was 100 days compared with 140 days in the control group. The healing rate at 12 weeks was equal to 46.2% in the honey group compared with 34.0% in the conventional group, and the difference in the healing rates (95% confidence interval, CI) at 12 weeks between the two groups was 12.2% (-13.6%, 37.9%). The unadjusted hazard ratio (95% CI) from a Cox regression was equal to 1.30 (0.77, 2.19), P = 0.321. When the treatment effect was adjusted for confounding factors (sex, wound type, age and wound area at start of treatment), the hazard ratio increased to 1.51 but was again not statistically significant.
CONCLUSION
Wound area at start of treatment and sex are both highly statistically significant predictors of time to healing. These results support the proposition that there are clinical benefits from using honey in wound care, but further research is needed.
DOI：
--
发表时间：
1972
期刊：
--
影响因子：
--
作者：
D. Cox
通讯作者：
D. Cox