Morphine modulates glutamate release in the hippocampal CA1 area in mice
Morphine modulates glutamate release in the hippocampal CA1 area in mice
复制标题
吗啡调节小鼠海马 CA1 区谷氨酸的释放。
DOI：
10.1016/j.neulet.2005.01.071
复制
发表时间：
2005-06-10
影响因子：
2.5
通讯作者：
Pei, G
中科院分区：
文献类型：
--
作者：
Guo, M;Xu, NH;Pei, G
阿片类药物滥用与大脑中持久的神经适应性变化有关。越来越多的证据表明阿片类药物显着改变谷氨酸能系统的功能，但该系统的调节方式仍然难以捉摸。在本研究中，我们研究了吗啡对海马体细胞外谷氨酸浓度的影响，海马体是富含谷氨酸能神经元的核。结果表明，急性或慢性吗啡治疗后，海马细胞外液中的谷氨酸浓度降低。然而，纳洛酮诱导的戒断会显着增加谷氨酸浓度。这些结果表明吗啡治疗后海马谷氨酸能神经元传递的适应。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Opiate abuse is associated with long-lasting neural adaptative changes in the brain. Increasing evidence demonstrates that opiates significantly alter the function of the glutamatergic system, while how the system is regulated still remains elusive. In the present study, we studied the effect of morphine on extracellular glutamate concentration in the hippocampus, a nucleus rich of the glutamatergic neurons. The results showed that glutamate concentration in the extracellular fluid of the hippocampus was decreased following either acute or chronic treatment of morphine. However, naloxone-induced withdrawal increased glutamate concentration significantly. These results suggest an adaptation of the glutamatergic neuronal transmission in the hippocampus after morphine treatment. (c) 2005 Elsevier Ireland Ltd. All rights reserved.